Targeting p53 and histone methyltransferases restores exhausted CD8+ T cells in HCV infection

Hepatitis C virus infection (HCV) represents a unique model to characterize, from early to late stages of infection, the T cell differentiation process leading to exhaustion of human CD8+ T cells. Here we show that in early HCV infection, exhaustion-committed virus-specific CD8+ T cells display a ma...

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Detalles Bibliográficos
Autores principales: Barili, Valeria, Fisicaro, Paola, Montanini, Barbara, Acerbi, Greta, Filippi, Anita, Forleo, Giovanna, Romualdi, Chiara, Ferracin, Manuela, Guerrieri, Francesca, Pedrazzi, Giuseppe, Boni, Carolina, Rossi, Marzia, Vecchi, Andrea, Penna, Amalia, Zecca, Alessandra, Mori, Cristina, Orlandini, Alessandra, Negri, Elisa, Pesci, Marco, Massari, Marco, Missale, Gabriele, Levrero, Massimo, Ottonello, Simone, Ferrari, Carlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992697/
https://www.ncbi.nlm.nih.gov/pubmed/32001678
http://dx.doi.org/10.1038/s41467-019-14137-7

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