Dual-mechanism based CTLs infiltration enhancement initiated by Nano-sapper potentiates immunotherapy against immune-excluded tumors

The failure of immunotherapies in immune-excluded tumor (IET) is largely ascribed to the void of intratumoral cytotoxic T cells (CTLs). The major obstacles are the excessive stroma, defective vasculatures and the deficiency of signals recruiting CTLs. Here we report a dual-mechanism based CTLs infil...

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Detalles Bibliográficos
Autores principales: Huang, Yukun, Chen, Yu, Zhou, Songlei, Chen, Liang, Wang, Jiahao, Pei, Yuanyuan, Xu, Minjun, Feng, Jingxian, Jiang, Tianze, Liang, Kaifan, Liu, Shanshan, Song, Qingxiang, Jiang, Gan, Gu, Xiao, Zhang, Qian, Gao, Xiaoling, Chen, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992734/
https://www.ncbi.nlm.nih.gov/pubmed/32001695
http://dx.doi.org/10.1038/s41467-020-14425-7

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