Targeting FROUNT with disulfiram suppresses macrophage accumulation and its tumor-promoting properties

Tumor-associated macrophages affect tumor progression and resistance to immune checkpoint therapy. Here, we identify the chemokine signal regulator FROUNT as a target to control tumor-associated macrophages. The low level FROUNT expression in patients with cancer correlates with better clinical outc...

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Detalles Bibliográficos
Autores principales: Terashima, Yuya, Toda, Etsuko, Itakura, Meiji, Otsuji, Mikiya, Yoshinaga, Sosuke, Okumura, Kazuhiro, Shand, Francis H. W., Komohara, Yoshihiro, Takeda, Mitsuhiro, Kokubo, Kana, Chen, Ming-Chen, Yokoi, Sana, Rokutan, Hirofumi, Kofuku, Yutaka, Ohnishi, Koji, Ohira, Miki, Iizasa, Toshihiko, Nakano, Hirofumi, Okabe, Takayoshi, Kojima, Hirotatsu, Shimizu, Akira, Kanegasaki, Shiro, Zhang, Ming-Rong, Shimada, Ichio, Nagase, Hiroki, Terasawa, Hiroaki, Matsushima, Kouji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992764/
https://www.ncbi.nlm.nih.gov/pubmed/32001710
http://dx.doi.org/10.1038/s41467-020-14338-5

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