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Gemcitabine induces Parkin-independent mitophagy through mitochondrial-resident E3 ligase MUL1-mediated stabilization of PINK1
Mitophagy plays an important role in the maintenance of mitochondrial homeostasis. PTEN-induced kinase (PINK1), a key regulator of mitophagy, is degraded constitutively under steady-state conditions. During mitophagy, it becomes stabilized in the outer mitochondrial membrane, particularly under mito...
Autores principales: | Igarashi, Ryoko, Yamashita, Shun-ichi, Yamashita, Tomohiro, Inoue, Keiichi, Fukuda, Tomoyuki, Fukuchi, Takeo, Kanki, Tomotake |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992789/ https://www.ncbi.nlm.nih.gov/pubmed/32001742 http://dx.doi.org/10.1038/s41598-020-58315-w |
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