Macrophages directly contribute collagen to scar formation during zebrafish heart regeneration and mouse heart repair

Canonical roles for macrophages in mediating the fibrotic response after a heart attack include extracellular matrix turnover and activation of cardiac fibroblasts to initiate collagen deposition. Here we reveal that macrophages directly contribute collagen to the forming post-injury scar. Unbiased...

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Detalles Bibliográficos
Autores principales: Simões, Filipa C., Cahill, Thomas J., Kenyon, Amy, Gavriouchkina, Daria, Vieira, Joaquim M., Sun, Xin, Pezzolla, Daniela, Ravaud, Christophe, Masmanian, Eva, Weinberger, Michael, Mayes, Sarah, Lemieux, Madeleine E., Barnette, Damien N., Gunadasa-Rohling, Mala, Williams, Ruth M., Greaves, David R., Trinh, Le A., Fraser, Scott E., Dallas, Sarah L., Choudhury, Robin P., Sauka-Spengler, Tatjana, Riley, Paul R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992796/
https://www.ncbi.nlm.nih.gov/pubmed/32001677
http://dx.doi.org/10.1038/s41467-019-14263-2

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