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PI3K inhibitors in thrombosis and cardiovascular disease
Phosphoinositide 3-kinases (PI3Ks) are lipid kinases that regulate important intracellular signalling and vesicle trafficking events via the generation of 3-phosphoinositides. Comprising eight core isoforms across three classes, the PI3K family displays broad expression and function throughout mamma...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992830/ https://www.ncbi.nlm.nih.gov/pubmed/32002690 http://dx.doi.org/10.1186/s40169-020-0261-6 |
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author | Durrant, Tom N. Hers, Ingeborg |
author_facet | Durrant, Tom N. Hers, Ingeborg |
author_sort | Durrant, Tom N. |
collection | PubMed |
description | Phosphoinositide 3-kinases (PI3Ks) are lipid kinases that regulate important intracellular signalling and vesicle trafficking events via the generation of 3-phosphoinositides. Comprising eight core isoforms across three classes, the PI3K family displays broad expression and function throughout mammalian tissues, and the (patho)physiological roles of these enzymes in the cardiovascular system present the PI3Ks as potential therapeutic targets in settings such as thrombosis, atherosclerosis and heart failure. This review will discuss the PI3K enzymes and their roles in cardiovascular physiology and disease, with a particular focus on platelet function and thrombosis. The current progress and future potential of targeting the PI3K enzymes for therapeutic benefit in cardiovascular disease will be considered, while the challenges of developing drugs against these master cellular regulators will be discussed. |
format | Online Article Text |
id | pubmed-6992830 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-69928302020-02-14 PI3K inhibitors in thrombosis and cardiovascular disease Durrant, Tom N. Hers, Ingeborg Clin Transl Med Review Phosphoinositide 3-kinases (PI3Ks) are lipid kinases that regulate important intracellular signalling and vesicle trafficking events via the generation of 3-phosphoinositides. Comprising eight core isoforms across three classes, the PI3K family displays broad expression and function throughout mammalian tissues, and the (patho)physiological roles of these enzymes in the cardiovascular system present the PI3Ks as potential therapeutic targets in settings such as thrombosis, atherosclerosis and heart failure. This review will discuss the PI3K enzymes and their roles in cardiovascular physiology and disease, with a particular focus on platelet function and thrombosis. The current progress and future potential of targeting the PI3K enzymes for therapeutic benefit in cardiovascular disease will be considered, while the challenges of developing drugs against these master cellular regulators will be discussed. Springer Berlin Heidelberg 2020-01-31 /pmc/articles/PMC6992830/ /pubmed/32002690 http://dx.doi.org/10.1186/s40169-020-0261-6 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Review Durrant, Tom N. Hers, Ingeborg PI3K inhibitors in thrombosis and cardiovascular disease |
title | PI3K inhibitors in thrombosis and cardiovascular disease |
title_full | PI3K inhibitors in thrombosis and cardiovascular disease |
title_fullStr | PI3K inhibitors in thrombosis and cardiovascular disease |
title_full_unstemmed | PI3K inhibitors in thrombosis and cardiovascular disease |
title_short | PI3K inhibitors in thrombosis and cardiovascular disease |
title_sort | pi3k inhibitors in thrombosis and cardiovascular disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992830/ https://www.ncbi.nlm.nih.gov/pubmed/32002690 http://dx.doi.org/10.1186/s40169-020-0261-6 |
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