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Programmable polyketide biosynthesis platform for production of aromatic compounds in yeast
To accelerate the shift to bio-based production and overcome complicated functional implementation of natural and artificial biosynthetic pathways to industry relevant organisms, development of new, versatile, bio-based production platforms is required. Here we present a novel yeast-based platform f...
| Autores principales: | , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
KeAi Publishing
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992897/ https://www.ncbi.nlm.nih.gov/pubmed/32021916 http://dx.doi.org/10.1016/j.synbio.2020.01.004 |
| _version_ | 1783492925044293632 |
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| author | Jakočiūnas, Tadas Klitgaard, Andreas K. Kontou, Eftychia Eva Nielsen, Julie Bang Thomsen, Emil Romero-Suarez, David Blin, Kai Petzold, Christopher J. Gin, Jennifer W. Tong, Yaojun Gotfredsen, Charlotte Held Charusanti, Pep Frandsen, Rasmus J.N. Weber, Tilmann Lee, Sang Yup Jensen, Michael K. Keasling, Jay D. |
| author_facet | Jakočiūnas, Tadas Klitgaard, Andreas K. Kontou, Eftychia Eva Nielsen, Julie Bang Thomsen, Emil Romero-Suarez, David Blin, Kai Petzold, Christopher J. Gin, Jennifer W. Tong, Yaojun Gotfredsen, Charlotte Held Charusanti, Pep Frandsen, Rasmus J.N. Weber, Tilmann Lee, Sang Yup Jensen, Michael K. Keasling, Jay D. |
| author_sort | Jakočiūnas, Tadas |
| collection | PubMed |
| description | To accelerate the shift to bio-based production and overcome complicated functional implementation of natural and artificial biosynthetic pathways to industry relevant organisms, development of new, versatile, bio-based production platforms is required. Here we present a novel yeast-based platform for biosynthesis of bacterial aromatic polyketides. The platform is based on a synthetic polyketide synthase system enabling a first demonstration of bacterial aromatic polyketide biosynthesis in a eukaryotic host. |
| format | Online Article Text |
| id | pubmed-6992897 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | KeAi Publishing |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-69928972020-02-04 Programmable polyketide biosynthesis platform for production of aromatic compounds in yeast Jakočiūnas, Tadas Klitgaard, Andreas K. Kontou, Eftychia Eva Nielsen, Julie Bang Thomsen, Emil Romero-Suarez, David Blin, Kai Petzold, Christopher J. Gin, Jennifer W. Tong, Yaojun Gotfredsen, Charlotte Held Charusanti, Pep Frandsen, Rasmus J.N. Weber, Tilmann Lee, Sang Yup Jensen, Michael K. Keasling, Jay D. Synth Syst Biotechnol Article To accelerate the shift to bio-based production and overcome complicated functional implementation of natural and artificial biosynthetic pathways to industry relevant organisms, development of new, versatile, bio-based production platforms is required. Here we present a novel yeast-based platform for biosynthesis of bacterial aromatic polyketides. The platform is based on a synthetic polyketide synthase system enabling a first demonstration of bacterial aromatic polyketide biosynthesis in a eukaryotic host. KeAi Publishing 2020-01-23 /pmc/articles/PMC6992897/ /pubmed/32021916 http://dx.doi.org/10.1016/j.synbio.2020.01.004 Text en © 2020 Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Article Jakočiūnas, Tadas Klitgaard, Andreas K. Kontou, Eftychia Eva Nielsen, Julie Bang Thomsen, Emil Romero-Suarez, David Blin, Kai Petzold, Christopher J. Gin, Jennifer W. Tong, Yaojun Gotfredsen, Charlotte Held Charusanti, Pep Frandsen, Rasmus J.N. Weber, Tilmann Lee, Sang Yup Jensen, Michael K. Keasling, Jay D. Programmable polyketide biosynthesis platform for production of aromatic compounds in yeast |
| title | Programmable polyketide biosynthesis platform for production of aromatic compounds in yeast |
| title_full | Programmable polyketide biosynthesis platform for production of aromatic compounds in yeast |
| title_fullStr | Programmable polyketide biosynthesis platform for production of aromatic compounds in yeast |
| title_full_unstemmed | Programmable polyketide biosynthesis platform for production of aromatic compounds in yeast |
| title_short | Programmable polyketide biosynthesis platform for production of aromatic compounds in yeast |
| title_sort | programmable polyketide biosynthesis platform for production of aromatic compounds in yeast |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992897/ https://www.ncbi.nlm.nih.gov/pubmed/32021916 http://dx.doi.org/10.1016/j.synbio.2020.01.004 |
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