The Exploration of Aroyltrimethylgermane as Potent Synthetic Origins and Their Preparation

The synthetic utilities of acylgermanes are surprisingly rarely explored compared with their analogues. In this communication, the survey of aroyltrimethylgermane as potent synthetic origins has been studied. A variety of novel chemical transformations have been realized, including using the acylger...

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Detalles Bibliográficos
Autores principales: Yuan, Yang, Zhang, Youcan, Chen, Bo, Wu, Xiao-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992900/
https://www.ncbi.nlm.nih.gov/pubmed/31958754
http://dx.doi.org/10.1016/j.isci.2019.100771
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author Yuan, Yang
Zhang, Youcan
Chen, Bo
Wu, Xiao-Feng
author_facet Yuan, Yang
Zhang, Youcan
Chen, Bo
Wu, Xiao-Feng
author_sort Yuan, Yang
collection PubMed
description The synthetic utilities of acylgermanes are surprisingly rarely explored compared with their analogues. In this communication, the survey of aroyltrimethylgermane as potent synthetic origins has been studied. A variety of novel chemical transformations have been realized, including using the acylgermane group as a directing group in Rh-catalyzed aromatic C-H alkenylation reaction and Ir-catalyzed aromatic C-H amidation reactions. Additionally, a general approach for acylgermanes preparation has been established as well. The catalytic system proceeds effectively in the presence of Pd(OAc)(2)/BINOL-based monophosphite (L11) and allows for the straightforward access to a wide range of functionalized acylgermanes in high yields.
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spelling pubmed-69929002020-02-03 The Exploration of Aroyltrimethylgermane as Potent Synthetic Origins and Their Preparation Yuan, Yang Zhang, Youcan Chen, Bo Wu, Xiao-Feng iScience Article The synthetic utilities of acylgermanes are surprisingly rarely explored compared with their analogues. In this communication, the survey of aroyltrimethylgermane as potent synthetic origins has been studied. A variety of novel chemical transformations have been realized, including using the acylgermane group as a directing group in Rh-catalyzed aromatic C-H alkenylation reaction and Ir-catalyzed aromatic C-H amidation reactions. Additionally, a general approach for acylgermanes preparation has been established as well. The catalytic system proceeds effectively in the presence of Pd(OAc)(2)/BINOL-based monophosphite (L11) and allows for the straightforward access to a wide range of functionalized acylgermanes in high yields. Elsevier 2019-12-14 /pmc/articles/PMC6992900/ /pubmed/31958754 http://dx.doi.org/10.1016/j.isci.2019.100771 Text en © 2019 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Yuan, Yang
Zhang, Youcan
Chen, Bo
Wu, Xiao-Feng
The Exploration of Aroyltrimethylgermane as Potent Synthetic Origins and Their Preparation
title The Exploration of Aroyltrimethylgermane as Potent Synthetic Origins and Their Preparation
title_full The Exploration of Aroyltrimethylgermane as Potent Synthetic Origins and Their Preparation
title_fullStr The Exploration of Aroyltrimethylgermane as Potent Synthetic Origins and Their Preparation
title_full_unstemmed The Exploration of Aroyltrimethylgermane as Potent Synthetic Origins and Their Preparation
title_short The Exploration of Aroyltrimethylgermane as Potent Synthetic Origins and Their Preparation
title_sort exploration of aroyltrimethylgermane as potent synthetic origins and their preparation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992900/
https://www.ncbi.nlm.nih.gov/pubmed/31958754
http://dx.doi.org/10.1016/j.isci.2019.100771
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