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Altered microtubule structure, hemichannel localization and beating activity in cardiomyocytes expressing pathologic nuclear lamin A/C

Given the clinical effect of laminopathies, understanding lamin mechanical properties will benefit the treatment of heart failure. Here we report a mechano-dynamic study of LMNA mutations in neonatal rat ventricular myocytes (NRVM) using single cell spectroscopy with Atomic Force Microscopy (AFM) an...

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Detalles Bibliográficos
Autores principales:	Borin, Daniele, Peña, Brisa, Chen, Suet Nee, Long, Carlin S., Taylor, Matthew R.G., Mestroni, Luisa, Sbaizero, Orfeo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992992/ https://www.ncbi.nlm.nih.gov/pubmed/32021920 http://dx.doi.org/10.1016/j.heliyon.2020.e03175

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