CBP mediated DOT1L acetylation confers DOT1L stability and promotes cancer metastasis

Background and Aim: DOT1L regulates various genes involved in cancer onset and progression by catalyzing H3K79 methylation, but how DOT1L activity itself is regulated is unclear. Here, we aimed to identify specific DOT1L post-translational modifications that might regulate DOT1L activity and thus im...

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Detalles Bibliográficos
Autores principales: Liu, Chaohua, Yang, Qiaoyan, Zhu, Qian, Lu, Xiaopeng, Li, Meiting, Hou, Tianyun, Li, Zhiming, Tang, Ming, Li, Yinglu, Wang, Hui, Yang, Yang, Wang, Haiying, Zhao, Ying, Wen, He, Liu, Xiangyu, Mao, Zebin, Zhu, Wei-Guo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6993218/
https://www.ncbi.nlm.nih.gov/pubmed/32042335
http://dx.doi.org/10.7150/thno.39013

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