UCH-L1-mediated Down-regulation of Estrogen Receptor α Contributes to Insensitivity to Endocrine Therapy for Breast Cancer

Purpose: To determine the role of UCH-L1 in regulating ERα expression, and to evaluate whether therapeutic targeting of UCH-L1 can enhance the efficacy of anti-estrogen therapy against breast cancer with loss or reduction of ERα. Methods: Expressions of UCH-L1 and ERα were examined in breast cancer...

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Detalles Bibliográficos
Autores principales: Chen, Xi-Sha, Wang, Kuan-Song, Guo, Wei, Li, Lan-Ya, Yu, Pian, Sun, Xin-Yuan, Wang, Hai-Yan, Guan, Yi-Di, Tao, Yong-Guang, Ding, Bo-Ni, Yin, Ming-Zhu, Ren, Xing-Cong, Zhang, Yi, Chen, Ce-Shi, Ye, Yuan-Chao, Yang, Jin-Ming, Cheng, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6993235/
https://www.ncbi.nlm.nih.gov/pubmed/32042339
http://dx.doi.org/10.7150/thno.39814

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