Shear stress activates ATOH8 via autocrine VEGF promoting glycolysis dependent-survival of colorectal cancer cells in the circulation

BACKGROUND: Metastasis and recurrence, wherein circulating tumour cells (CTCs) play an important role, are the leading causes of death in colorectal cancer (CRC). Metastasis-initiating CTCs manage to maintain intravascular survival under anoikis, immune attack, and importantly shear stress; however,...

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Detalles Bibliográficos
Autores principales: Huang, Qiong, Li, Shaowei, Hu, Xingbin, Sun, Mengting, Wu, Qijing, Dai, Huiru, Tan, Yujing, Sun, Fei, Wang, Chunlin, Rong, Xiaoxiang, Liao, Wangjun, Peng, Jianjun, Xiao, Jianjun, Huang, Li, Wang, Jiao, Liang, Bishan, Lin, Kelin, Liu, Yajing, Shi, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6993408/
https://www.ncbi.nlm.nih.gov/pubmed/32000836
http://dx.doi.org/10.1186/s13046-020-1533-0

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