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A novel chalcone derivative has antitumor activity in melanoma by inducing DNA damage through the upregulation of ROS products

BACKGROUND: Melanoma is one of the most aggressive tumors with the remarkable characteristic of resistance to traditional chemotherapy and radiotherapy. Although targeted therapy and immunotherapy benefit advanced melanoma patient treatment, BRAFi (BRAF inhibitor) resistance and the lower response r...

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Detalles Bibliográficos
Autores principales:	Li, Keke, Zhao, Shuang, Long, Jing, Su, Juan, Wu, Lisha, Tao, Juan, Zhou, Jianda, Zhang, JiangLin, Chen, Xiang, Peng, Cong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6993520/ https://www.ncbi.nlm.nih.gov/pubmed/32021565 http://dx.doi.org/10.1186/s12935-020-1114-5

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