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Outcomes of Bone Marrow Mononuclear Cell Transplantation for Neurological Sequelae Due to Intracranial Hemorrhage Incidence in the Neonatal Period: Report of Four Cases

Aim: The aim of this study was to present primary outcomes of autologous bone marrow mononuclear cell (BMMNC) transplantation to improve neurological sequelae in four children with intracranial hemorrhage (ICH) incidence during the neonatal period. Methods: GMFM88 and modified Ashworth score were us...

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Autores principales: Liem, Nguyen Thanh, Huyen, Truong Linh, Huong, Le Thu, Doan, Ngo Van, Anh, Bui Viet, Anh, Nguyen Thi Phuong, Tung, Dang Thanh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6993568/
https://www.ncbi.nlm.nih.gov/pubmed/32039110
http://dx.doi.org/10.3389/fped.2019.00543
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author Liem, Nguyen Thanh
Huyen, Truong Linh
Huong, Le Thu
Doan, Ngo Van
Anh, Bui Viet
Anh, Nguyen Thi Phuong
Tung, Dang Thanh
author_facet Liem, Nguyen Thanh
Huyen, Truong Linh
Huong, Le Thu
Doan, Ngo Van
Anh, Bui Viet
Anh, Nguyen Thi Phuong
Tung, Dang Thanh
author_sort Liem, Nguyen Thanh
collection PubMed
description Aim: The aim of this study was to present primary outcomes of autologous bone marrow mononuclear cell (BMMNC) transplantation to improve neurological sequelae in four children with intracranial hemorrhage (ICH) incidence during the neonatal period. Methods: GMFM88 and modified Ashworth score were used to assess motor function and muscle spasticity before BMMNC transplantation and after transplantation. Brain MRI was performed to evaluate brain morphology before and after BMMNC transplantation. Bone marrow were harvested from anterior iliac crest puncture and BMMNCs were isolated using Ficoll gradient centrifugation. The microbiological testing, cell counting, and hematopoietic stem cell (hHSC CD34+ cell) analysis were performed, following which BMMNCs were infused intrathecally. Results: Improvement in motor function was observed in all patients after transplantation. In addition, muscle spasticity was reduced in all four patients. Conclusion: Autologous BMMNC transplantation may improve motor function and reduce muscle spasticity in children with ICH incidence during the neonatal period.
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spelling pubmed-69935682020-02-07 Outcomes of Bone Marrow Mononuclear Cell Transplantation for Neurological Sequelae Due to Intracranial Hemorrhage Incidence in the Neonatal Period: Report of Four Cases Liem, Nguyen Thanh Huyen, Truong Linh Huong, Le Thu Doan, Ngo Van Anh, Bui Viet Anh, Nguyen Thi Phuong Tung, Dang Thanh Front Pediatr Pediatrics Aim: The aim of this study was to present primary outcomes of autologous bone marrow mononuclear cell (BMMNC) transplantation to improve neurological sequelae in four children with intracranial hemorrhage (ICH) incidence during the neonatal period. Methods: GMFM88 and modified Ashworth score were used to assess motor function and muscle spasticity before BMMNC transplantation and after transplantation. Brain MRI was performed to evaluate brain morphology before and after BMMNC transplantation. Bone marrow were harvested from anterior iliac crest puncture and BMMNCs were isolated using Ficoll gradient centrifugation. The microbiological testing, cell counting, and hematopoietic stem cell (hHSC CD34+ cell) analysis were performed, following which BMMNCs were infused intrathecally. Results: Improvement in motor function was observed in all patients after transplantation. In addition, muscle spasticity was reduced in all four patients. Conclusion: Autologous BMMNC transplantation may improve motor function and reduce muscle spasticity in children with ICH incidence during the neonatal period. Frontiers Media S.A. 2020-01-24 /pmc/articles/PMC6993568/ /pubmed/32039110 http://dx.doi.org/10.3389/fped.2019.00543 Text en Copyright © 2020 Liem, Huyen, Huong, Doan, Anh, Anh and Tung. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Liem, Nguyen Thanh
Huyen, Truong Linh
Huong, Le Thu
Doan, Ngo Van
Anh, Bui Viet
Anh, Nguyen Thi Phuong
Tung, Dang Thanh
Outcomes of Bone Marrow Mononuclear Cell Transplantation for Neurological Sequelae Due to Intracranial Hemorrhage Incidence in the Neonatal Period: Report of Four Cases
title Outcomes of Bone Marrow Mononuclear Cell Transplantation for Neurological Sequelae Due to Intracranial Hemorrhage Incidence in the Neonatal Period: Report of Four Cases
title_full Outcomes of Bone Marrow Mononuclear Cell Transplantation for Neurological Sequelae Due to Intracranial Hemorrhage Incidence in the Neonatal Period: Report of Four Cases
title_fullStr Outcomes of Bone Marrow Mononuclear Cell Transplantation for Neurological Sequelae Due to Intracranial Hemorrhage Incidence in the Neonatal Period: Report of Four Cases
title_full_unstemmed Outcomes of Bone Marrow Mononuclear Cell Transplantation for Neurological Sequelae Due to Intracranial Hemorrhage Incidence in the Neonatal Period: Report of Four Cases
title_short Outcomes of Bone Marrow Mononuclear Cell Transplantation for Neurological Sequelae Due to Intracranial Hemorrhage Incidence in the Neonatal Period: Report of Four Cases
title_sort outcomes of bone marrow mononuclear cell transplantation for neurological sequelae due to intracranial hemorrhage incidence in the neonatal period: report of four cases
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6993568/
https://www.ncbi.nlm.nih.gov/pubmed/32039110
http://dx.doi.org/10.3389/fped.2019.00543
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