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Correlation Between Apparent Diffusion Coefficient Value on MRI and Histopathologic WHO Grades of Neuroendocrine Tumors

BACKGROUND: The correlation of diffusion-weighted MRI and tumor aggressiveness has been established for different tumor types, which leads to the question if it could also apply for neuroendocrine tumors (NET). PURPOSE: To investigate the possible correlation between apparent diffusion coefficient (...

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Autores principales: Mebis, Wouter, Snoeckx, Annemiek, Corthouts, Bob, El Addouli, Haroun, Nicolay, Simon, Van Hoyweghen, Astrid, Spinhoven, Maarten, de Beeck, Bart Op
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ubiquity Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6993591/
https://www.ncbi.nlm.nih.gov/pubmed/32025623
http://dx.doi.org/10.5334/jbsr.1925
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author Mebis, Wouter
Snoeckx, Annemiek
Corthouts, Bob
El Addouli, Haroun
Nicolay, Simon
Van Hoyweghen, Astrid
Spinhoven, Maarten
de Beeck, Bart Op
author_facet Mebis, Wouter
Snoeckx, Annemiek
Corthouts, Bob
El Addouli, Haroun
Nicolay, Simon
Van Hoyweghen, Astrid
Spinhoven, Maarten
de Beeck, Bart Op
author_sort Mebis, Wouter
collection PubMed
description BACKGROUND: The correlation of diffusion-weighted MRI and tumor aggressiveness has been established for different tumor types, which leads to the question if it could also apply for neuroendocrine tumors (NET). PURPOSE: To investigate the possible correlation between apparent diffusion coefficient (ADC) value on magnetic resonance imaging (MRI) and histopathologic WHO-grades of NET. MATERIAL AND METHODS: Electronic patient records from patients presented at the multidisciplinary neuro-endocrine tumor board between November 2017 and April 2019 were retrospectively reviewed. Patients with both available MR imaging (primary tumor or metastasis) and known WHO tumor grade were included (n = 47). Average and minimum ADC values (avgADC; minADC) were measured by drawing a freehand ROI excluding only the outermost border of the lesion. The largest axial size (primary tumor) or most clearly delineated lesion (metastasis) was used. RESULTS: Forty seven patients met the inclusion criteria (mean age 59 ± 12 SD; 24F/23M). Twenty one patients (45%) were diagnosed with WHO G1 tumor, 17 seventeen with G2 (36%) and nine with G3 (19%) tumor. Twenty eight primary tumors and 19 metastases were measured. A significant difference was found between low-grade (G1+G2) and high-grade (G3) tumors (Mann-Whitney; avgADC: p < 0,001; minADC: p = 0,001). There was a moderate negative correlation between WHO-grade and avgADC/minADC (Spearman; avgADC: –0,606; 95% CI [–0,773; –0,384]; minADC: –0,581; 95% CI [–0.759; –0.353]). CONCLUSION: Our data show a significant difference in both average and minimum ADC values on MRI between low and high grade NET. A moderate negative correlation was found between histopathologic WHO grade and ADC value.
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spelling pubmed-69935912020-02-05 Correlation Between Apparent Diffusion Coefficient Value on MRI and Histopathologic WHO Grades of Neuroendocrine Tumors Mebis, Wouter Snoeckx, Annemiek Corthouts, Bob El Addouli, Haroun Nicolay, Simon Van Hoyweghen, Astrid Spinhoven, Maarten de Beeck, Bart Op J Belg Soc Radiol Original Article BACKGROUND: The correlation of diffusion-weighted MRI and tumor aggressiveness has been established for different tumor types, which leads to the question if it could also apply for neuroendocrine tumors (NET). PURPOSE: To investigate the possible correlation between apparent diffusion coefficient (ADC) value on magnetic resonance imaging (MRI) and histopathologic WHO-grades of NET. MATERIAL AND METHODS: Electronic patient records from patients presented at the multidisciplinary neuro-endocrine tumor board between November 2017 and April 2019 were retrospectively reviewed. Patients with both available MR imaging (primary tumor or metastasis) and known WHO tumor grade were included (n = 47). Average and minimum ADC values (avgADC; minADC) were measured by drawing a freehand ROI excluding only the outermost border of the lesion. The largest axial size (primary tumor) or most clearly delineated lesion (metastasis) was used. RESULTS: Forty seven patients met the inclusion criteria (mean age 59 ± 12 SD; 24F/23M). Twenty one patients (45%) were diagnosed with WHO G1 tumor, 17 seventeen with G2 (36%) and nine with G3 (19%) tumor. Twenty eight primary tumors and 19 metastases were measured. A significant difference was found between low-grade (G1+G2) and high-grade (G3) tumors (Mann-Whitney; avgADC: p < 0,001; minADC: p = 0,001). There was a moderate negative correlation between WHO-grade and avgADC/minADC (Spearman; avgADC: –0,606; 95% CI [–0,773; –0,384]; minADC: –0,581; 95% CI [–0.759; –0.353]). CONCLUSION: Our data show a significant difference in both average and minimum ADC values on MRI between low and high grade NET. A moderate negative correlation was found between histopathologic WHO grade and ADC value. Ubiquity Press 2020-01-30 /pmc/articles/PMC6993591/ /pubmed/32025623 http://dx.doi.org/10.5334/jbsr.1925 Text en Copyright: © 2020 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC-BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See http://creativecommons.org/licenses/by/4.0/.
spellingShingle Original Article
Mebis, Wouter
Snoeckx, Annemiek
Corthouts, Bob
El Addouli, Haroun
Nicolay, Simon
Van Hoyweghen, Astrid
Spinhoven, Maarten
de Beeck, Bart Op
Correlation Between Apparent Diffusion Coefficient Value on MRI and Histopathologic WHO Grades of Neuroendocrine Tumors
title Correlation Between Apparent Diffusion Coefficient Value on MRI and Histopathologic WHO Grades of Neuroendocrine Tumors
title_full Correlation Between Apparent Diffusion Coefficient Value on MRI and Histopathologic WHO Grades of Neuroendocrine Tumors
title_fullStr Correlation Between Apparent Diffusion Coefficient Value on MRI and Histopathologic WHO Grades of Neuroendocrine Tumors
title_full_unstemmed Correlation Between Apparent Diffusion Coefficient Value on MRI and Histopathologic WHO Grades of Neuroendocrine Tumors
title_short Correlation Between Apparent Diffusion Coefficient Value on MRI and Histopathologic WHO Grades of Neuroendocrine Tumors
title_sort correlation between apparent diffusion coefficient value on mri and histopathologic who grades of neuroendocrine tumors
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6993591/
https://www.ncbi.nlm.nih.gov/pubmed/32025623
http://dx.doi.org/10.5334/jbsr.1925
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