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A dual functional ruthenium arene complex induces differentiation and apoptosis of acute promyelocytic leukemia cells

Human acute promyelocytic leukemia (APL) is the most malignant form of acute leukemia. The fusion of PML and RARα genes is responsible for over 98% of cases of APL. In this work, we found that a Ru(ii) arene complex, [(η(6)-p-bip)Ru(en)Cl][PF(6)] (Ru-1), can selectively react with PML, leading to zi...

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Detalles Bibliográficos
Autores principales:	Huang, Hai, Cao, Kaiming, Kong, Yaqiong, Yuan, Siming, Liu, Hongke, Wang, Yucai, Liu, Yangzhong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2019
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6993625/ https://www.ncbi.nlm.nih.gov/pubmed/32055340 http://dx.doi.org/10.1039/c9sc03110c

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