Repurposing human kinase inhibitors to create an antibiotic active against drug-resistant Staphylococcus aureus, persisters and biofilms

New drugs are desperately needed to combat methicillin-resistant Staphylococcus aureus (MRSA) infections. Here we report screening commercial kinase inhibitors for anti-bacterial activity and found the anti-cancer drug sorafenib as major hit effectively killing MRSA strains. Varying the key structur...

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Detalles Bibliográficos
Autores principales: Le, Philipp, Kunold, Elena, Macsics, Robert, Rox, Katharina, Jennings, Megan C., Ugur, Ilke, Reinecke, Maria, Chaves-Moreno, Diego, Hackl, Mathias W., Fetzer, Christian, Mandl, Franziska A. M., Lehmann, Johannes, Korotkov, Vadim S., Hacker, Stephan M., Kuster, Bernhard, Antes, Iris, Pieper, Dietmar H., Rohde, Manfred, Wuest, William M., Medina, Eva, Sieber, Stephan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994260/
https://www.ncbi.nlm.nih.gov/pubmed/31844194
http://dx.doi.org/10.1038/s41557-019-0378-7

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