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Variation in early life maternal care predicts later long range frontal cortex synapse development in mice

Empirical and theoretical work suggests that early postnatal experience may inform later developing synaptic connectivity to adapt the brain to its environment. We hypothesized that early maternal experience may program the development of synaptic density on long range frontal cortex projections. To...

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Autores principales: Thomas, A. Wren, Delevich, Kristen, Chang, Irene, Wilbrecht, Linda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994474/
https://www.ncbi.nlm.nih.gov/pubmed/31786477
http://dx.doi.org/10.1016/j.dcn.2019.100737
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author Thomas, A. Wren
Delevich, Kristen
Chang, Irene
Wilbrecht, Linda
author_facet Thomas, A. Wren
Delevich, Kristen
Chang, Irene
Wilbrecht, Linda
author_sort Thomas, A. Wren
collection PubMed
description Empirical and theoretical work suggests that early postnatal experience may inform later developing synaptic connectivity to adapt the brain to its environment. We hypothesized that early maternal experience may program the development of synaptic density on long range frontal cortex projections. To test this idea, we used maternal separation (MS) to generate environmental variability and examined how MS affected 1) maternal care and 2) synapse density on virally-labeled long range axons of offspring reared in MS or control conditions. We found that MS and variation in maternal care predicted bouton density on dorsal frontal cortex axons that terminated in the basolateral amygdala (BLA) and dorsomedial striatum (DMS) with more, fragmented care associated with higher density. The effects of maternal care on these distinct axonal projections of the frontal cortex were manifest at different ages. Maternal care measures were correlated with frontal cortex → BLA bouton density at mid-adolescence postnatal (P) day 35 and frontal cortex → DMS bouton density in adulthood (P85). Meanwhile, we found no evidence that MS or maternal care affected bouton density on ascending orbitofrontal cortex (OFC) or BLA axons that terminated in the dorsal frontal cortices. Our data show that variation in early experience can alter development in a circuit-specific and age-dependent manner that may be relevant to understanding the effects of early life adversity.
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spelling pubmed-69944742020-02-04 Variation in early life maternal care predicts later long range frontal cortex synapse development in mice Thomas, A. Wren Delevich, Kristen Chang, Irene Wilbrecht, Linda Dev Cogn Neurosci Articles from the Special Issue on Flux 2018: Mechanisms of Learning & Plasticity; Edited by Catherine Hartley, Yana Fandakova, Silvia Bunge, Eveline Crone, Ulman Lindenberger. Empirical and theoretical work suggests that early postnatal experience may inform later developing synaptic connectivity to adapt the brain to its environment. We hypothesized that early maternal experience may program the development of synaptic density on long range frontal cortex projections. To test this idea, we used maternal separation (MS) to generate environmental variability and examined how MS affected 1) maternal care and 2) synapse density on virally-labeled long range axons of offspring reared in MS or control conditions. We found that MS and variation in maternal care predicted bouton density on dorsal frontal cortex axons that terminated in the basolateral amygdala (BLA) and dorsomedial striatum (DMS) with more, fragmented care associated with higher density. The effects of maternal care on these distinct axonal projections of the frontal cortex were manifest at different ages. Maternal care measures were correlated with frontal cortex → BLA bouton density at mid-adolescence postnatal (P) day 35 and frontal cortex → DMS bouton density in adulthood (P85). Meanwhile, we found no evidence that MS or maternal care affected bouton density on ascending orbitofrontal cortex (OFC) or BLA axons that terminated in the dorsal frontal cortices. Our data show that variation in early experience can alter development in a circuit-specific and age-dependent manner that may be relevant to understanding the effects of early life adversity. Elsevier 2019-11-20 /pmc/articles/PMC6994474/ /pubmed/31786477 http://dx.doi.org/10.1016/j.dcn.2019.100737 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Articles from the Special Issue on Flux 2018: Mechanisms of Learning & Plasticity; Edited by Catherine Hartley, Yana Fandakova, Silvia Bunge, Eveline Crone, Ulman Lindenberger.
Thomas, A. Wren
Delevich, Kristen
Chang, Irene
Wilbrecht, Linda
Variation in early life maternal care predicts later long range frontal cortex synapse development in mice
title Variation in early life maternal care predicts later long range frontal cortex synapse development in mice
title_full Variation in early life maternal care predicts later long range frontal cortex synapse development in mice
title_fullStr Variation in early life maternal care predicts later long range frontal cortex synapse development in mice
title_full_unstemmed Variation in early life maternal care predicts later long range frontal cortex synapse development in mice
title_short Variation in early life maternal care predicts later long range frontal cortex synapse development in mice
title_sort variation in early life maternal care predicts later long range frontal cortex synapse development in mice
topic Articles from the Special Issue on Flux 2018: Mechanisms of Learning & Plasticity; Edited by Catherine Hartley, Yana Fandakova, Silvia Bunge, Eveline Crone, Ulman Lindenberger.
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994474/
https://www.ncbi.nlm.nih.gov/pubmed/31786477
http://dx.doi.org/10.1016/j.dcn.2019.100737
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