Expanding the genome-targeting scope and the site selectivity of high-precision base editors

Base editors (BEs) are RNA-guided CRISPR-Cas-derived genome editing tools that induce single-nucleotide changes. The limitations of current BEs lie in their low precision (especially when multiple target nucleotides of the deaminase are present within the activity window) and their restriction to ta...

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Detalles Bibliográficos
Autores principales: Tan, Junjie, Zhang, Fei, Karcher, Daniel, Bock, Ralph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994485/
https://www.ncbi.nlm.nih.gov/pubmed/32005820
http://dx.doi.org/10.1038/s41467-020-14465-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994485/
https://www.ncbi.nlm.nih.gov/pubmed/32005820
http://dx.doi.org/10.1038/s41467-020-14465-z

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