Mitochondrial MUL1 E3 ubiquitin ligase regulates Hypoxia Inducible Factor (HIF-1α) and metabolic reprogramming by modulating the UBXN7 cofactor protein

MUL1 is a multifunctional E3 ubiquitin ligase anchored in the outer mitochondrial membrane with its RING finger domain facing the cytoplasm. MUL1 participates in various biological pathways involved in apoptosis, mitochondrial dynamics, and innate immune response. The unique topology of MUL1 enables...

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Detalles Bibliográficos
Autores principales: Cilenti, Lucia, Di Gregorio, Jacopo, Ambivero, Camilla T., Andl, Thomas, Liao, Ronglih, Zervos, Antonis S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994496/
https://www.ncbi.nlm.nih.gov/pubmed/32005965
http://dx.doi.org/10.1038/s41598-020-58484-8

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