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Multi-drug therapy for epilepsy influenced bispectral index after a bolus propofol administration without affecting propofol’s pharmacokinetics: a prospective cohort study

Some previous studies have indicated that valproate (VPA) might change the pharmacokinetics and enhance the effects of propofol. We evaluated whether clinical VPA therapy affected the propofol blood level, the protein-unbound free propofol level, and/or the anesthetic effects of propofol in the clin...

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Detalles Bibliográficos
Autores principales:	Kodama, Matsuri, Higuchi, Hitoshi, Ishii-Maruhama, Minako, Nakano, Mai, Honda-Wakasugi, Yuka, Maeda, Shigeru, Miyawaki, Takuya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994638/ https://www.ncbi.nlm.nih.gov/pubmed/32005870 http://dx.doi.org/10.1038/s41598-020-58460-2

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