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Elucidating target specificity of the taccalonolide covalent microtubule stabilizers employing a combinatorial chemical approach
The taccalonolide microtubule stabilizers covalently bind β-tubulin and overcome clinically relevant taxane resistance mechanisms. Evaluations of the target specificity and detailed drug–target interactions of taccalonolides, however, have been limited in part by their irreversible target engagement...
Autores principales: | Du, Lin, Yee, Samantha S., Ramachandran, Karthik, Risinger, April L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994698/ https://www.ncbi.nlm.nih.gov/pubmed/32005831 http://dx.doi.org/10.1038/s41467-019-14277-w |
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