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Gut microbiome structure and adrenocortical activity in dogs with aggressive and phobic behavioral disorders
Accompanying human beings since the Paleolithic period, dogs has been recently regarded as a reliable model for the study of the gut microbiome connections with health and disease. In order to provide some glimpses on the connections between the gut microbiome layout and host behavior, we profiled t...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994854/ https://www.ncbi.nlm.nih.gov/pubmed/32021942 http://dx.doi.org/10.1016/j.heliyon.2020.e03311 |
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author | Mondo, E. Barone, M. Soverini, M. D'Amico, F. Cocchi, M. Petrulli, C. Mattioli, M. Marliani, G. Candela, M. Accorsi, P.A. |
author_facet | Mondo, E. Barone, M. Soverini, M. D'Amico, F. Cocchi, M. Petrulli, C. Mattioli, M. Marliani, G. Candela, M. Accorsi, P.A. |
author_sort | Mondo, E. |
collection | PubMed |
description | Accompanying human beings since the Paleolithic period, dogs has been recently regarded as a reliable model for the study of the gut microbiome connections with health and disease. In order to provide some glimpses on the connections between the gut microbiome layout and host behavior, we profiled the phylogenetic composition and structure of the canine gut microbiome of dogs with aggressive (n = 11), phobic (n = 13) and normal behavior (n = 18). Hormones’ determination was made through Radio Immuno-Assay (RIA), and next generation sequencing of the V3–V4 gene region of the bacterial 16S rRNA was employed to determine gut microbiome composition. Our results did not evidence any significant differences of hormonal levels between the three groups. According to our findings, aggressive behavioral disorder was found to be characterized by a peculiar gut microbiome structure, with high biodiversity and enrichment in generally subdominant bacterial genera (i.e. Catenibacterium and Megamonas). On the other hand, phobic dogs were enriched in Lactobacillus, a bacterial genus with known probiotic and psychobiotic properties. Although further studies are needed to validate our findings, our work supports the intriguing opportunity that different behavioral phenotypes in dogs may be associated with peculiar gut microbiome layouts, suggesting possible connections between the gut microbiome and the central nervous system and indicating the possible adoption of probiotic interventions aimed at restoring a balanced host-symbiont interplay for mitigating behavioral disorders. |
format | Online Article Text |
id | pubmed-6994854 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-69948542020-02-04 Gut microbiome structure and adrenocortical activity in dogs with aggressive and phobic behavioral disorders Mondo, E. Barone, M. Soverini, M. D'Amico, F. Cocchi, M. Petrulli, C. Mattioli, M. Marliani, G. Candela, M. Accorsi, P.A. Heliyon Article Accompanying human beings since the Paleolithic period, dogs has been recently regarded as a reliable model for the study of the gut microbiome connections with health and disease. In order to provide some glimpses on the connections between the gut microbiome layout and host behavior, we profiled the phylogenetic composition and structure of the canine gut microbiome of dogs with aggressive (n = 11), phobic (n = 13) and normal behavior (n = 18). Hormones’ determination was made through Radio Immuno-Assay (RIA), and next generation sequencing of the V3–V4 gene region of the bacterial 16S rRNA was employed to determine gut microbiome composition. Our results did not evidence any significant differences of hormonal levels between the three groups. According to our findings, aggressive behavioral disorder was found to be characterized by a peculiar gut microbiome structure, with high biodiversity and enrichment in generally subdominant bacterial genera (i.e. Catenibacterium and Megamonas). On the other hand, phobic dogs were enriched in Lactobacillus, a bacterial genus with known probiotic and psychobiotic properties. Although further studies are needed to validate our findings, our work supports the intriguing opportunity that different behavioral phenotypes in dogs may be associated with peculiar gut microbiome layouts, suggesting possible connections between the gut microbiome and the central nervous system and indicating the possible adoption of probiotic interventions aimed at restoring a balanced host-symbiont interplay for mitigating behavioral disorders. Elsevier 2020-01-29 /pmc/articles/PMC6994854/ /pubmed/32021942 http://dx.doi.org/10.1016/j.heliyon.2020.e03311 Text en © 2020 The Authors. Published by Elsevier Ltd. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Mondo, E. Barone, M. Soverini, M. D'Amico, F. Cocchi, M. Petrulli, C. Mattioli, M. Marliani, G. Candela, M. Accorsi, P.A. Gut microbiome structure and adrenocortical activity in dogs with aggressive and phobic behavioral disorders |
title | Gut microbiome structure and adrenocortical activity in dogs with aggressive and phobic behavioral disorders |
title_full | Gut microbiome structure and adrenocortical activity in dogs with aggressive and phobic behavioral disorders |
title_fullStr | Gut microbiome structure and adrenocortical activity in dogs with aggressive and phobic behavioral disorders |
title_full_unstemmed | Gut microbiome structure and adrenocortical activity in dogs with aggressive and phobic behavioral disorders |
title_short | Gut microbiome structure and adrenocortical activity in dogs with aggressive and phobic behavioral disorders |
title_sort | gut microbiome structure and adrenocortical activity in dogs with aggressive and phobic behavioral disorders |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994854/ https://www.ncbi.nlm.nih.gov/pubmed/32021942 http://dx.doi.org/10.1016/j.heliyon.2020.e03311 |
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