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Gut microbiome structure and adrenocortical activity in dogs with aggressive and phobic behavioral disorders

Accompanying human beings since the Paleolithic period, dogs has been recently regarded as a reliable model for the study of the gut microbiome connections with health and disease. In order to provide some glimpses on the connections between the gut microbiome layout and host behavior, we profiled t...

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Autores principales: Mondo, E., Barone, M., Soverini, M., D'Amico, F., Cocchi, M., Petrulli, C., Mattioli, M., Marliani, G., Candela, M., Accorsi, P.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994854/
https://www.ncbi.nlm.nih.gov/pubmed/32021942
http://dx.doi.org/10.1016/j.heliyon.2020.e03311
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author Mondo, E.
Barone, M.
Soverini, M.
D'Amico, F.
Cocchi, M.
Petrulli, C.
Mattioli, M.
Marliani, G.
Candela, M.
Accorsi, P.A.
author_facet Mondo, E.
Barone, M.
Soverini, M.
D'Amico, F.
Cocchi, M.
Petrulli, C.
Mattioli, M.
Marliani, G.
Candela, M.
Accorsi, P.A.
author_sort Mondo, E.
collection PubMed
description Accompanying human beings since the Paleolithic period, dogs has been recently regarded as a reliable model for the study of the gut microbiome connections with health and disease. In order to provide some glimpses on the connections between the gut microbiome layout and host behavior, we profiled the phylogenetic composition and structure of the canine gut microbiome of dogs with aggressive (n = 11), phobic (n = 13) and normal behavior (n = 18). Hormones’ determination was made through Radio Immuno-Assay (RIA), and next generation sequencing of the V3–V4 gene region of the bacterial 16S rRNA was employed to determine gut microbiome composition. Our results did not evidence any significant differences of hormonal levels between the three groups. According to our findings, aggressive behavioral disorder was found to be characterized by a peculiar gut microbiome structure, with high biodiversity and enrichment in generally subdominant bacterial genera (i.e. Catenibacterium and Megamonas). On the other hand, phobic dogs were enriched in Lactobacillus, a bacterial genus with known probiotic and psychobiotic properties. Although further studies are needed to validate our findings, our work supports the intriguing opportunity that different behavioral phenotypes in dogs may be associated with peculiar gut microbiome layouts, suggesting possible connections between the gut microbiome and the central nervous system and indicating the possible adoption of probiotic interventions aimed at restoring a balanced host-symbiont interplay for mitigating behavioral disorders.
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spelling pubmed-69948542020-02-04 Gut microbiome structure and adrenocortical activity in dogs with aggressive and phobic behavioral disorders Mondo, E. Barone, M. Soverini, M. D'Amico, F. Cocchi, M. Petrulli, C. Mattioli, M. Marliani, G. Candela, M. Accorsi, P.A. Heliyon Article Accompanying human beings since the Paleolithic period, dogs has been recently regarded as a reliable model for the study of the gut microbiome connections with health and disease. In order to provide some glimpses on the connections between the gut microbiome layout and host behavior, we profiled the phylogenetic composition and structure of the canine gut microbiome of dogs with aggressive (n = 11), phobic (n = 13) and normal behavior (n = 18). Hormones’ determination was made through Radio Immuno-Assay (RIA), and next generation sequencing of the V3–V4 gene region of the bacterial 16S rRNA was employed to determine gut microbiome composition. Our results did not evidence any significant differences of hormonal levels between the three groups. According to our findings, aggressive behavioral disorder was found to be characterized by a peculiar gut microbiome structure, with high biodiversity and enrichment in generally subdominant bacterial genera (i.e. Catenibacterium and Megamonas). On the other hand, phobic dogs were enriched in Lactobacillus, a bacterial genus with known probiotic and psychobiotic properties. Although further studies are needed to validate our findings, our work supports the intriguing opportunity that different behavioral phenotypes in dogs may be associated with peculiar gut microbiome layouts, suggesting possible connections between the gut microbiome and the central nervous system and indicating the possible adoption of probiotic interventions aimed at restoring a balanced host-symbiont interplay for mitigating behavioral disorders. Elsevier 2020-01-29 /pmc/articles/PMC6994854/ /pubmed/32021942 http://dx.doi.org/10.1016/j.heliyon.2020.e03311 Text en © 2020 The Authors. Published by Elsevier Ltd. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mondo, E.
Barone, M.
Soverini, M.
D'Amico, F.
Cocchi, M.
Petrulli, C.
Mattioli, M.
Marliani, G.
Candela, M.
Accorsi, P.A.
Gut microbiome structure and adrenocortical activity in dogs with aggressive and phobic behavioral disorders
title Gut microbiome structure and adrenocortical activity in dogs with aggressive and phobic behavioral disorders
title_full Gut microbiome structure and adrenocortical activity in dogs with aggressive and phobic behavioral disorders
title_fullStr Gut microbiome structure and adrenocortical activity in dogs with aggressive and phobic behavioral disorders
title_full_unstemmed Gut microbiome structure and adrenocortical activity in dogs with aggressive and phobic behavioral disorders
title_short Gut microbiome structure and adrenocortical activity in dogs with aggressive and phobic behavioral disorders
title_sort gut microbiome structure and adrenocortical activity in dogs with aggressive and phobic behavioral disorders
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994854/
https://www.ncbi.nlm.nih.gov/pubmed/32021942
http://dx.doi.org/10.1016/j.heliyon.2020.e03311
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