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Prevalence of latent tuberculosis infection in healthcare workers in tertiary care hospitals of Pakistan

OBJECTIVE: To determine the prevalence of latent tuberculosis infection (LTBI) in healthcare workers in tertiary care hospitals of Rawalpindi, using interferon gamma release assay. METHODS: It was a cross-sectional study. The samples were collected from pulmonology and microbiology departments of th...

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Autores principales: Sadaf, Rabia, Munir, Tehmina, Farrukh, Sheroze, Abbasi, Saleem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Professional Medical Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994889/
https://www.ncbi.nlm.nih.gov/pubmed/32063959
http://dx.doi.org/10.12669/pjms.36.2.936
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author Sadaf, Rabia
Munir, Tehmina
Farrukh, Sheroze
Abbasi, Saleem
author_facet Sadaf, Rabia
Munir, Tehmina
Farrukh, Sheroze
Abbasi, Saleem
author_sort Sadaf, Rabia
collection PubMed
description OBJECTIVE: To determine the prevalence of latent tuberculosis infection (LTBI) in healthcare workers in tertiary care hospitals of Rawalpindi, using interferon gamma release assay. METHODS: It was a cross-sectional study. The samples were collected from pulmonology and microbiology departments of three hospitals; i) Military Hospital, Rawalpindi, ii) Fauji Foundation Hospital, Rawalpindi and iii) Pakistan Institute of Medical Sciences, Islamabad. The study was completed in one year from January 2017 to January 2018. Fifty-five asymptomatic healthcare workers of both genders between the ages of 18-50 years with a working tenure of at least one year in concerned departments were included and those with active tuberculosis were excluded from the study. Whole blood from subjects was collected and plasma was checked for interferon gamma value by IGRA (Interferon gamma release assay). RESULTS: In this study of total 55 healthcare workers a high prevalence 22 (40.0%) of latent tuberculosis was found. When LTBI distribution was analyzed within occupational categories, the most frequently affected were sanitary workers 3 (100.0%), nurses 5 (50.0%), doctors 6 (43%) and nursing assistants 2 (40%). CONCLUSION: The prevalence of LTBI in healthcare workers is alarmingly high in our local healthcare settings.
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spelling pubmed-69948892020-02-14 Prevalence of latent tuberculosis infection in healthcare workers in tertiary care hospitals of Pakistan Sadaf, Rabia Munir, Tehmina Farrukh, Sheroze Abbasi, Saleem Pak J Med Sci Original Article OBJECTIVE: To determine the prevalence of latent tuberculosis infection (LTBI) in healthcare workers in tertiary care hospitals of Rawalpindi, using interferon gamma release assay. METHODS: It was a cross-sectional study. The samples were collected from pulmonology and microbiology departments of three hospitals; i) Military Hospital, Rawalpindi, ii) Fauji Foundation Hospital, Rawalpindi and iii) Pakistan Institute of Medical Sciences, Islamabad. The study was completed in one year from January 2017 to January 2018. Fifty-five asymptomatic healthcare workers of both genders between the ages of 18-50 years with a working tenure of at least one year in concerned departments were included and those with active tuberculosis were excluded from the study. Whole blood from subjects was collected and plasma was checked for interferon gamma value by IGRA (Interferon gamma release assay). RESULTS: In this study of total 55 healthcare workers a high prevalence 22 (40.0%) of latent tuberculosis was found. When LTBI distribution was analyzed within occupational categories, the most frequently affected were sanitary workers 3 (100.0%), nurses 5 (50.0%), doctors 6 (43%) and nursing assistants 2 (40%). CONCLUSION: The prevalence of LTBI in healthcare workers is alarmingly high in our local healthcare settings. Professional Medical Publications 2020 /pmc/articles/PMC6994889/ /pubmed/32063959 http://dx.doi.org/10.12669/pjms.36.2.936 Text en Copyright: © Pakistan Journal of Medical Sciences http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Sadaf, Rabia
Munir, Tehmina
Farrukh, Sheroze
Abbasi, Saleem
Prevalence of latent tuberculosis infection in healthcare workers in tertiary care hospitals of Pakistan
title Prevalence of latent tuberculosis infection in healthcare workers in tertiary care hospitals of Pakistan
title_full Prevalence of latent tuberculosis infection in healthcare workers in tertiary care hospitals of Pakistan
title_fullStr Prevalence of latent tuberculosis infection in healthcare workers in tertiary care hospitals of Pakistan
title_full_unstemmed Prevalence of latent tuberculosis infection in healthcare workers in tertiary care hospitals of Pakistan
title_short Prevalence of latent tuberculosis infection in healthcare workers in tertiary care hospitals of Pakistan
title_sort prevalence of latent tuberculosis infection in healthcare workers in tertiary care hospitals of pakistan
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994889/
https://www.ncbi.nlm.nih.gov/pubmed/32063959
http://dx.doi.org/10.12669/pjms.36.2.936
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