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Hemogram parameters in the patients with subacute thyroiditis
BACKGROUND &OBJECTIVE: Subacute Granulomatous Thyroiditis (De Quervain’s Thyroiditis) is an acute painful inflammatory disease of the thyroid. We aimed to investigate easily accessible and cheap hemogram based parameters of Neutrophil to Lymphocyte Ratio (NLR), Platelet to Lymphocyte Ratio (PLR)...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Professional Medical Publications
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994909/ https://www.ncbi.nlm.nih.gov/pubmed/32063967 http://dx.doi.org/10.12669/pjms.36.2.1063 |
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author | Cengiz, Hasret Varim, Ceyhun Demirci, Taner Cetin, Sedat |
author_facet | Cengiz, Hasret Varim, Ceyhun Demirci, Taner Cetin, Sedat |
author_sort | Cengiz, Hasret |
collection | PubMed |
description | BACKGROUND &OBJECTIVE: Subacute Granulomatous Thyroiditis (De Quervain’s Thyroiditis) is an acute painful inflammatory disease of the thyroid. We aimed to investigate easily accessible and cheap hemogram based parameters of Neutrophil to Lymphocyte Ratio (NLR), Platelet to Lymphocyte Ratio (PLR), and Mean Platelet Volume (MPV) in the follow up of inflammatory thyroid disease. METHODS: Patients admitted to Sakarya University Education and Research Hospital Endocrinology and Metabolism Outpatient Clinic and diagnosed as Subacute Granulomatous Thyroiditis between May 2017 and November 2018 were included in the study. Hemogram, thyroid function tests and acute phase values of these patients were recorded and compared with the values after treatment and disease recovery. On the sixth month, thyroid function tests were repeated and the rate of permanent hypothyroidism was screened. The relationships between initial hemogram parameters and acute phase reactants were evaluated. RESULTS: Total 71 patients were included in our study. 60 (84.5%) were female and 11 (15.5%) were male. The F/M ratio was found to be 6/1. Mean age was 43 ± 9.95 years. Receiver Operating Characteristics (ROC) Curve Analysis was performed and values for Area Under the Curve (AUC) for NLR and PLR, respectively, were 0.739 (95% CI 0.657-0.820 p<0.0001) and 0.772 (95% CI 0.694-0.850 p<0.0001), which are significant and associated with disease activity. However, the AUC for MPV parameter was: 0.578 (95% CI 0.484-0.672 P(:) 0.10) and was not significant. The cut off values defined as 2.4 (80% sensitivity and 51% specificity) for NLR and 146.84 (83% sensitivity and 54% specificity) for PLR for the acute phase of the disease. In the Correlation Analysis, NLR and PLR values were significantly correlated with ESR and CRP parameters, which are the most commonly used acute phase reactants. CONCLUSION: According to the present study, we believe that the NLR and PLR parameters will be of benefit in the follow-up the disease, accurately demonstrate the inflammatory load in the acute phase of the disease, and correlate with the common acute phase reactants. |
format | Online Article Text |
id | pubmed-6994909 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Professional Medical Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-69949092020-02-14 Hemogram parameters in the patients with subacute thyroiditis Cengiz, Hasret Varim, Ceyhun Demirci, Taner Cetin, Sedat Pak J Med Sci Original Article BACKGROUND &OBJECTIVE: Subacute Granulomatous Thyroiditis (De Quervain’s Thyroiditis) is an acute painful inflammatory disease of the thyroid. We aimed to investigate easily accessible and cheap hemogram based parameters of Neutrophil to Lymphocyte Ratio (NLR), Platelet to Lymphocyte Ratio (PLR), and Mean Platelet Volume (MPV) in the follow up of inflammatory thyroid disease. METHODS: Patients admitted to Sakarya University Education and Research Hospital Endocrinology and Metabolism Outpatient Clinic and diagnosed as Subacute Granulomatous Thyroiditis between May 2017 and November 2018 were included in the study. Hemogram, thyroid function tests and acute phase values of these patients were recorded and compared with the values after treatment and disease recovery. On the sixth month, thyroid function tests were repeated and the rate of permanent hypothyroidism was screened. The relationships between initial hemogram parameters and acute phase reactants were evaluated. RESULTS: Total 71 patients were included in our study. 60 (84.5%) were female and 11 (15.5%) were male. The F/M ratio was found to be 6/1. Mean age was 43 ± 9.95 years. Receiver Operating Characteristics (ROC) Curve Analysis was performed and values for Area Under the Curve (AUC) for NLR and PLR, respectively, were 0.739 (95% CI 0.657-0.820 p<0.0001) and 0.772 (95% CI 0.694-0.850 p<0.0001), which are significant and associated with disease activity. However, the AUC for MPV parameter was: 0.578 (95% CI 0.484-0.672 P(:) 0.10) and was not significant. The cut off values defined as 2.4 (80% sensitivity and 51% specificity) for NLR and 146.84 (83% sensitivity and 54% specificity) for PLR for the acute phase of the disease. In the Correlation Analysis, NLR and PLR values were significantly correlated with ESR and CRP parameters, which are the most commonly used acute phase reactants. CONCLUSION: According to the present study, we believe that the NLR and PLR parameters will be of benefit in the follow-up the disease, accurately demonstrate the inflammatory load in the acute phase of the disease, and correlate with the common acute phase reactants. Professional Medical Publications 2020 /pmc/articles/PMC6994909/ /pubmed/32063967 http://dx.doi.org/10.12669/pjms.36.2.1063 Text en Copyright: © Pakistan Journal of Medical Sciences http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Cengiz, Hasret Varim, Ceyhun Demirci, Taner Cetin, Sedat Hemogram parameters in the patients with subacute thyroiditis |
title | Hemogram parameters in the patients with subacute thyroiditis |
title_full | Hemogram parameters in the patients with subacute thyroiditis |
title_fullStr | Hemogram parameters in the patients with subacute thyroiditis |
title_full_unstemmed | Hemogram parameters in the patients with subacute thyroiditis |
title_short | Hemogram parameters in the patients with subacute thyroiditis |
title_sort | hemogram parameters in the patients with subacute thyroiditis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994909/ https://www.ncbi.nlm.nih.gov/pubmed/32063967 http://dx.doi.org/10.12669/pjms.36.2.1063 |
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