Cargando…
The nutrient sensor OGT regulates Hipk stability and tumorigenic-like activities in Drosophila
Environmental cues such as nutrients alter cellular behaviors by acting on a wide array of molecular sensors inside cells. Of emerging interest is the link observed between effects of dietary sugars on cancer proliferation. Here, we identify the requirements of hexosamine biosynthetic pathway (HBP)...
Autores principales: | Wong, Kenneth Kin Lam, Liu, Ta-Wei, Parker, Jessica M., Sinclair, Donald A. R., Chen, Yi-Yun, Khoo, Kay-Hooi, Vocadlo, David J., Verheyen, Esther M. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994980/ https://www.ncbi.nlm.nih.gov/pubmed/31932432 http://dx.doi.org/10.1073/pnas.1912894117 |
Ejemplares similares
-
Hyperpolarized mitochondria accumulate in Drosophila Hipk-overexpressing cells to drive tumor-like growth
por: Wong, Kenneth Kin Lam, et al.
Publicado: (2020) -
The AMPK-like protein kinases Sik2 and Sik3 interact with Hipk and induce synergistic tumorigenesis in a Drosophila cancer model
por: Yu, Kewei, et al.
Publicado: (2023) -
Expression of human HIPKs in Drosophila demonstrates their shared and unique functions in a developmental model
por: Kinsey, Stephen D, et al.
Publicado: (2021) -
Nutrient Sensor mTOR and OGT: Orchestrators of Organelle Homeostasis in Pancreatic β-Cells
por: Esch, Nicholas, et al.
Publicado: (2020) -
Hipk is required for JAK/STAT activity during development and tumorigenesis
por: Tettweiler, Gritta, et al.
Publicado: (2019)