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Innate immune receptor NOD2 mediates LGR5(+) intestinal stem cell protection against ROS cytotoxicity via mitophagy stimulation

The nucleotide-binding oligomerization domain-containing protein 2 (NOD2) agonist muramyl dipeptide (MDP), a peptidoglycan motif common to all bacteria, supports leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5)(+) intestinal stem cell (ISC) survival through NOD2 activation upon an...

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Detalles Bibliográficos
Autores principales:	Levy, Antonin, Stedman, Aline, Deutsch, Eric, Donnadieu, Françoise, Virgin, Herbert W., Sansonetti, Philippe J., Nigro, Giulia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2020
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994981/ https://www.ncbi.nlm.nih.gov/pubmed/31919280 http://dx.doi.org/10.1073/pnas.1902788117

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