A long-distance rRNA base pair impacts the ability of macrolide antibiotics to kill bacteria

While most of the ribosome-targeting antibiotics are bacteriostatic, some members of the macrolide class demonstrate considerable bactericidal activity. We previously showed that an extended alkyl-aryl side chain is the key structural element determining the macrolides’ slow dissociation from the ri...

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Detalles Bibliográficos
Autores principales: Svetlov, Maxim S., Cohen, Sophie, Alsuhebany, Nada, Vázquez-Laslop, Nora, Mankin, Alexander S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995004/
https://www.ncbi.nlm.nih.gov/pubmed/31932436
http://dx.doi.org/10.1073/pnas.1918948117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995004/
https://www.ncbi.nlm.nih.gov/pubmed/31932436
http://dx.doi.org/10.1073/pnas.1918948117

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