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A long-distance rRNA base pair impacts the ability of macrolide antibiotics to kill bacteria
While most of the ribosome-targeting antibiotics are bacteriostatic, some members of the macrolide class demonstrate considerable bactericidal activity. We previously showed that an extended alkyl-aryl side chain is the key structural element determining the macrolides’ slow dissociation from the ri...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995004/ https://www.ncbi.nlm.nih.gov/pubmed/31932436 http://dx.doi.org/10.1073/pnas.1918948117 |