HSD3B1 genotype identifies glucocorticoid responsiveness in severe asthma

Asthma resistance to glucocorticoid treatment is a major health problem with unclear etiology. Glucocorticoids inhibit adrenal androgen production. However, androgens have potential benefits in asthma. HSD3B1 encodes for 3β-hydroxysteroid dehydrogenase-1 (3β-HSD1), which catalyzes peripheral convers...

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Detalles Bibliográficos
Autores principales: Zein, Joe, Gaston, Benjamin, Bazeley, Peter, DeBoer, Mark D., Igo, Robert P., Bleecker, Eugene R., Meyers, Deborah, Comhair, Suzy, Marozkina, Nadzeya V., Cotton, Calvin, Patel, Mona, Alyamani, Mohammad, Xu, Weiling, Busse, William W., Calhoun, William J., Ortega, Victor, Hawkins, Gregory A., Castro, Mario, Chung, Kian Fan, Fahy, John V., Fitzpatrick, Anne M., Israel, Elliot, Jarjour, Nizar N., Levy, Bruce, Mauger, David T., Moore, Wendy C., Noel, Patricia, Peters, Stephen P., Teague, W. Gerald, Wenzel, Sally E., Erzurum, Serpil C., Sharifi, Nima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995013/
https://www.ncbi.nlm.nih.gov/pubmed/31932420
http://dx.doi.org/10.1073/pnas.1918819117

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