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Amphotericin B biosynthesis in Streptomyces nodosus: quantitative analysis of metabolism via LC–MS/MS based metabolomics for rational design

BACKGROUND: Amphotericin B (AmB) is widely used against fungal infection and produced mainly by Streptomyces nodosus. Various intracellular metabolites of S. nodosus were identified during AmB fermentation, and the key compounds that related to the cell growth and biosynthesis of AmB were analyzed b...

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Detalles Bibliográficos
Autores principales:	Zhang, Bo, Zhou, Yi-Teng, Jiang, Sheng-Xian, Zhang, Yu-Han, Huang, Kai, Liu, Zhi-Qiang, Zheng, Yu-Guo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995120/ https://www.ncbi.nlm.nih.gov/pubmed/32005241 http://dx.doi.org/10.1186/s12934-020-1290-y

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