Cargando…
A New Validated HPLC-MS/MS Method for Quantification and Pharmacokinetic Evaluation of Dovitinib, a Multi-Kinase Inhibitor, in Mouse Plasma
BACKGROUND: Dovitinib (TKI 258) is a small-molecule multi-kinase inhibitor for the treatment of different types of cancer. There is currently no validated method for its quantitative determination; therefore, we aimed to develop a reliable method to assay dovitinib. METHOD AND RESULTS: An electrospr...
Autores principales: | AlRabiah, Haitham, Kadi, Adnan A, Aljohar, Haya I, Attwa, Mohamed W, Al-Shakliah, Nasser S, Attia, Sabry M, Mostafa, Gamal AE |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995292/ https://www.ncbi.nlm.nih.gov/pubmed/32095071 http://dx.doi.org/10.2147/DDDT.S223573 |
Ejemplares similares
-
Development of an LC-MS/MS Method for Quantification of Sapitinib in Human Liver Microsomes: In Silico and In Vitro Metabolic Stability Evaluation
por: Attwa, Mohamed W., et al.
Publicado: (2023) -
Profiling of in vivo, in vitro and reactive zorifertinib metabolites using liquid chromatography ion trap mass spectrometry
por: Al-Shakliah, Nasser S., et al.
Publicado: (2022) -
Development and Validation of an HPLC-UV Detection Assay for the Determination of Clonidine in Mouse Plasma and Its Application to a Pharmacokinetic Study
por: AlRabiah, Haitham, et al.
Publicado: (2020) -
Assessment of In Silico and In Vitro Selpercatinib Metabolic Stability in Human Liver Microsomes Using a Validated LC-MS/MS Method
por: Attwa, Mohamed W., et al.
Publicado: (2023) -
Validated LC-MS/MS assay for quantification of the newly approved tyrosine kinase inhibitor, dacomitinib, and application to investigating its metabolic stability
por: Abdelhameed, Ali S., et al.
Publicado: (2019)