Cargando…

Long-Lasting Effects of GSPE on Ileal GLP-1R Gene Expression Are Associated with a Hypomethylation of the GLP-1R Promoter in Female Wistar Rats

Flavonoids have been shown to modulate GLP-1 in obesity. GLP-1 induces some of its effects through the intestinal GLP-1 receptor (GLP-1R), though no data exist on how flavonoids affect this receptor. Here, we examine how a dose of grape seed proanthocyanidin extract (GSPE) with anti-obesity activity...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ginés, Iris, Gil-Cardoso, Katherine, D’Addario, Claudio, Falconi, Anastasia, Bellia, Fabio, Blay, M Teresa, Terra, Ximena, Ardévol, Anna, Pinent, Montserrat, Beltrán-Debón, Raúl
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995503/ https://www.ncbi.nlm.nih.gov/pubmed/31842341 http://dx.doi.org/10.3390/biom9120865

Ejemplares similares

Glucagon Shows Higher Sensitivity than Insulin to Grapeseed Proanthocyanidin Extract (GSPE) Treatment in Cafeteria-Fed Rats
por: Grau-Bové, Carme, et al.
Publicado: (2021)

Intestinal Morphometric Changes Induced by a Western-Style Diet in Wistar Rats and GSPE Counter-Regulatory Effect
por: Segú, Helena, et al.
Publicado: (2022)

GSPE Pre-Treatment Exerts Long-Lasting Preventive Effects against Aging-Induced Changes in the Colonic Enterohormone Profile of Female Rats
por: Miguéns-Gómez, Alba, et al.
Publicado: (2023)

Effects of an Intermittent Grape-Seed Proanthocyanidin (GSPE) Treatment on a Cafeteria Diet Obesogenic Challenge in Rats
por: Ginés, Iris, et al.
Publicado: (2018)

Grape-Seed Proanthocyanidins are Able to Reverse Intestinal Dysfunction and Metabolic Endotoxemia Induced by a Cafeteria Diet in Wistar Rats
por: González-Quilen, Carlos, et al.
Publicado: (2019)

GLP1 Exerts Paracrine Activity in the Intestinal Lumen of Human Colon
por: Grau-Bové, Carme, et al.
Publicado: (2022)

The Hidden One: What We Know About Bitter Taste Receptor 39
por: Jalševac, Florijan, et al.
Publicado: (2022)

Health-Promoting Properties of Proanthocyanidins for Intestinal Dysfunction
por: González-Quilen, Carlos, et al.
Publicado: (2020)

Effect of an Acute Insect Preload vs. an Almond Preload on Energy Intake, Subjective Food Consumption and Intestinal Health in Healthy Young Adults
por: Miguéns-Gómez, Alba, et al.
Publicado: (2022)

Bitter taste receptors along the gastrointestinal tract: comparison between humans and rodents
por: Descamps-Solà, Maria, et al.
Publicado: (2023)

Effects of Flavanols on Enteroendocrine Secretion
por: Grau-Bové, Carme, et al.
Publicado: (2020)

A Ten-Day Grape Seed Procyanidin Treatment Prevents Certain Ageing Processes in Female Rats over the Long Term
por: Grau-Bové, Carme, et al.
Publicado: (2020)

Grape-Seed Proanthocyanidin Extract Reverts Obesity-Related Metabolic Derangements in Aged Female Rats
por: Sierra-Cruz, Marta, et al.
Publicado: (2021)

Inhibition of DPP-IV Activity and Stimulation of GLP-1 Release by Gastrointestinally Digested Black Soldier Fly Prepupae
por: Luparelli, Anna Valentina, et al.
Publicado: (2023)

Modulation of Food Intake by Differential TAS2R Stimulation in Rat
por: Grau-Bové, Carme, et al.
Publicado: (2020)

Defining Conditions for Optimal Inhibition of Food Intake in Rats by a Grape-Seed Derived Proanthocyanidin Extract
por: Serrano, Joan, et al.
Publicado: (2016)

Acute selective bioactivity of grape seed proanthocyanidins on enteroendocrine secretions in the gastrointestinal tract
por: Casanova-Martí, Àngela, et al.
Publicado: (2017)

Administration of Alphitobius diaperinus or Tenebrio molitor before meals transiently increases food intake through enterohormone regulation in female rats
por: Miguéns‐Gómez, Alba, et al.
Publicado: (2022)

Proanthocyanidins Limit Adipose Accrual Induced by a Cafeteria Diet, Several Weeks after the End of the Treatment
por: Ginés, Iris, et al.
Publicado: (2019)

Gastrointestinally Digested Protein from the Insect Alphitobius diaperinus Stimulates a Different Intestinal Secretome than Beef or Almond, Producing a Differential Response in Food Intake in Rats
por: Miguéns-Gómez, Alba, et al.
Publicado: (2020)

Identification of a nutrient-sensing transcriptional network in monocytes by using inbred rat models on a cafeteria diet
por: Martínez-Micaelo, Neus, et al.
Publicado: (2016)

Effect of GLP-1/GLP-1R on the Polarization of Macrophages in the Occurrence and Development of Atherosclerosis
por: Yang, Li, et al.
Publicado: (2021)

Targeting the GLP-1/GLP-1R axis to treat osteoarthritis: A new opportunity?
por: Meurot, C., et al.
Publicado: (2022)

Mutagenesis facilitated crystallization of GLP-1R
por: Xu, Yueming, et al.
Publicado: (2019)

Distinct Identity of GLP-1R, GLP-2R, and GIPR Expressing Cells and Signaling Circuits Within the Gastrointestinal Tract
por: Morrow, Nadya M., et al.
Publicado: (2021)

THU264 Enteric Activity Enhanced Ileal GLP-1 Secretion
por: Chen, Yixin, et al.
Publicado: (2023)

Small peptide-based GLP-1R ligands: an approach to reduce the kidney uptake of radiolabeled GLP-1R-targeting agents?
por: Felber, Veronika Barbara, et al.
Publicado: (2021)

Inactivation of the cardiomyocyte glucagon-like peptide-1 receptor (GLP-1R) unmasks cardiomyocyte-independent GLP-1R-mediated cardioprotection()()
por: Ussher, John R., et al.
Publicado: (2014)

Exploring the GLP-1–GLP-1R axis in porcine pancreas and gastrointestinal tract in vivo by ex vivo autoradiography
por: Manell, Elin, et al.
Publicado: (2021)

Reagents and models for detecting endogenous GLP1R and GIPR
por: Ast, Julia, et al.
Publicado: (2021)

Anti-Inflammatory Effects of GLP-1R Activation in the Retina
por: Puddu, Alessandra, et al.
Publicado: (2022)

Structural analysis of the dual agonism at GLP-1R and GCGR
por: Li, Yang, et al.
Publicado: (2023)

GLP-1R Signaling and Functional Molecules in Incretin Therapy
por: Wan, Wenwei, et al.
Publicado: (2023)

Blockade of Central GLP-1 Receptors Deteriorates the Improvement of Diabetes after Ileal Transposition
por: Chen, Weijie, et al.
Publicado: (2016)

GLP2-GLP2R signal affects the viability and EGFR-TKIs sensitivity of PC9 and HCC827 cells
por: Song, Bin, et al.
Publicado: (2022)

Common Genetic Variation in GLP1R and Insulin Secretion in Response to Exogenous GLP-1 in Nondiabetic Subjects: A pilot study
por: Sathananthan, Airani, et al.
Publicado: (2010)

Designing a Dual GLP-1R/GIPR Agonist from Tirzepatide: Comparing Residues Between Tirzepatide, GLP-1, and GIP
por: Wang, Lijing
Publicado: (2022)

Pancreatic alpha cells in diabetic rats express active GLP-1 receptor: Endosomal co-localization of GLP-1/GLP-1R complex functioning through intra-islet paracrine mechanism
por: Nakashima, Koji, et al.
Publicado: (2018)

Labeling and Characterization of Human GLP-1-Secreting L-cells in Primary Ileal Organoid Culture
por: Goldspink, Deborah A., et al.
Publicado: (2020)

GLP-1R–Targeting Magnetic Nanoparticles for Pancreatic Islet Imaging
por: Wang, Ping, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_idt6tnn3teg02td231fdccbcjl