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Modulatory Mechanisms of the NLRP3 Inflammasomes in Diabetes
The inflammasome is a multiprotein complex that acts to enhance inflammatory responses by promoting the production and secretion of key cytokines. The best-known inflammasome is the NLRP3 (nucleotide-binding oligomerization domain-like receptor [NLR] family pyrin domain-containing 3) inflammasome. T...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995523/ https://www.ncbi.nlm.nih.gov/pubmed/31835423 http://dx.doi.org/10.3390/biom9120850 |
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author | Ding, Sujuan Xu, Sheng Ma, Yong Liu, Gang Jang, Hongmei Fang, Jun |
author_facet | Ding, Sujuan Xu, Sheng Ma, Yong Liu, Gang Jang, Hongmei Fang, Jun |
author_sort | Ding, Sujuan |
collection | PubMed |
description | The inflammasome is a multiprotein complex that acts to enhance inflammatory responses by promoting the production and secretion of key cytokines. The best-known inflammasome is the NLRP3 (nucleotide-binding oligomerization domain-like receptor [NLR] family pyrin domain-containing 3) inflammasome. The evidence has shown that the NLRP3 inflammasome, IL-1β, thioredoxin-interacting protein (TXNIP), and pyroptosis play vital roles in the development of diabetes. This review summarizes the regulation of type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) by NLRP3 via modulation of glucose tolerance, insulin resistance, inflammation, and apoptosis mediated by endoplasmic reticulum stress in adipose tissue. Moreover, NLRP3 participates in intestinal homeostasis and inflammatory conditions, and NLRP3-deficient mice experience intestinal lesions. The diversity of an individual’s gut microbiome and the resultant microbial metabolites determines the extent of their involvement in the physiological and pathological mechanisms within the gut. As such, further study of the interaction between the NLRP3 inflammasome and the complex intestinal environment in disease development is warranted to discover novel therapies for the treatment of diabetes. |
format | Online Article Text |
id | pubmed-6995523 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-69955232020-02-13 Modulatory Mechanisms of the NLRP3 Inflammasomes in Diabetes Ding, Sujuan Xu, Sheng Ma, Yong Liu, Gang Jang, Hongmei Fang, Jun Biomolecules Review The inflammasome is a multiprotein complex that acts to enhance inflammatory responses by promoting the production and secretion of key cytokines. The best-known inflammasome is the NLRP3 (nucleotide-binding oligomerization domain-like receptor [NLR] family pyrin domain-containing 3) inflammasome. The evidence has shown that the NLRP3 inflammasome, IL-1β, thioredoxin-interacting protein (TXNIP), and pyroptosis play vital roles in the development of diabetes. This review summarizes the regulation of type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) by NLRP3 via modulation of glucose tolerance, insulin resistance, inflammation, and apoptosis mediated by endoplasmic reticulum stress in adipose tissue. Moreover, NLRP3 participates in intestinal homeostasis and inflammatory conditions, and NLRP3-deficient mice experience intestinal lesions. The diversity of an individual’s gut microbiome and the resultant microbial metabolites determines the extent of their involvement in the physiological and pathological mechanisms within the gut. As such, further study of the interaction between the NLRP3 inflammasome and the complex intestinal environment in disease development is warranted to discover novel therapies for the treatment of diabetes. MDPI 2019-12-09 /pmc/articles/PMC6995523/ /pubmed/31835423 http://dx.doi.org/10.3390/biom9120850 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ding, Sujuan Xu, Sheng Ma, Yong Liu, Gang Jang, Hongmei Fang, Jun Modulatory Mechanisms of the NLRP3 Inflammasomes in Diabetes |
title | Modulatory Mechanisms of the NLRP3 Inflammasomes in Diabetes |
title_full | Modulatory Mechanisms of the NLRP3 Inflammasomes in Diabetes |
title_fullStr | Modulatory Mechanisms of the NLRP3 Inflammasomes in Diabetes |
title_full_unstemmed | Modulatory Mechanisms of the NLRP3 Inflammasomes in Diabetes |
title_short | Modulatory Mechanisms of the NLRP3 Inflammasomes in Diabetes |
title_sort | modulatory mechanisms of the nlrp3 inflammasomes in diabetes |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995523/ https://www.ncbi.nlm.nih.gov/pubmed/31835423 http://dx.doi.org/10.3390/biom9120850 |
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