Cargando…

Modulatory Mechanisms of the NLRP3 Inflammasomes in Diabetes

The inflammasome is a multiprotein complex that acts to enhance inflammatory responses by promoting the production and secretion of key cytokines. The best-known inflammasome is the NLRP3 (nucleotide-binding oligomerization domain-like receptor [NLR] family pyrin domain-containing 3) inflammasome. T...

Descripción completa

Detalles Bibliográficos
Autores principales: Ding, Sujuan, Xu, Sheng, Ma, Yong, Liu, Gang, Jang, Hongmei, Fang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995523/
https://www.ncbi.nlm.nih.gov/pubmed/31835423
http://dx.doi.org/10.3390/biom9120850
_version_ 1783493388185632768
author Ding, Sujuan
Xu, Sheng
Ma, Yong
Liu, Gang
Jang, Hongmei
Fang, Jun
author_facet Ding, Sujuan
Xu, Sheng
Ma, Yong
Liu, Gang
Jang, Hongmei
Fang, Jun
author_sort Ding, Sujuan
collection PubMed
description The inflammasome is a multiprotein complex that acts to enhance inflammatory responses by promoting the production and secretion of key cytokines. The best-known inflammasome is the NLRP3 (nucleotide-binding oligomerization domain-like receptor [NLR] family pyrin domain-containing 3) inflammasome. The evidence has shown that the NLRP3 inflammasome, IL-1β, thioredoxin-interacting protein (TXNIP), and pyroptosis play vital roles in the development of diabetes. This review summarizes the regulation of type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) by NLRP3 via modulation of glucose tolerance, insulin resistance, inflammation, and apoptosis mediated by endoplasmic reticulum stress in adipose tissue. Moreover, NLRP3 participates in intestinal homeostasis and inflammatory conditions, and NLRP3-deficient mice experience intestinal lesions. The diversity of an individual’s gut microbiome and the resultant microbial metabolites determines the extent of their involvement in the physiological and pathological mechanisms within the gut. As such, further study of the interaction between the NLRP3 inflammasome and the complex intestinal environment in disease development is warranted to discover novel therapies for the treatment of diabetes.
format Online
Article
Text
id pubmed-6995523
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-69955232020-02-13 Modulatory Mechanisms of the NLRP3 Inflammasomes in Diabetes Ding, Sujuan Xu, Sheng Ma, Yong Liu, Gang Jang, Hongmei Fang, Jun Biomolecules Review The inflammasome is a multiprotein complex that acts to enhance inflammatory responses by promoting the production and secretion of key cytokines. The best-known inflammasome is the NLRP3 (nucleotide-binding oligomerization domain-like receptor [NLR] family pyrin domain-containing 3) inflammasome. The evidence has shown that the NLRP3 inflammasome, IL-1β, thioredoxin-interacting protein (TXNIP), and pyroptosis play vital roles in the development of diabetes. This review summarizes the regulation of type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) by NLRP3 via modulation of glucose tolerance, insulin resistance, inflammation, and apoptosis mediated by endoplasmic reticulum stress in adipose tissue. Moreover, NLRP3 participates in intestinal homeostasis and inflammatory conditions, and NLRP3-deficient mice experience intestinal lesions. The diversity of an individual’s gut microbiome and the resultant microbial metabolites determines the extent of their involvement in the physiological and pathological mechanisms within the gut. As such, further study of the interaction between the NLRP3 inflammasome and the complex intestinal environment in disease development is warranted to discover novel therapies for the treatment of diabetes. MDPI 2019-12-09 /pmc/articles/PMC6995523/ /pubmed/31835423 http://dx.doi.org/10.3390/biom9120850 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ding, Sujuan
Xu, Sheng
Ma, Yong
Liu, Gang
Jang, Hongmei
Fang, Jun
Modulatory Mechanisms of the NLRP3 Inflammasomes in Diabetes
title Modulatory Mechanisms of the NLRP3 Inflammasomes in Diabetes
title_full Modulatory Mechanisms of the NLRP3 Inflammasomes in Diabetes
title_fullStr Modulatory Mechanisms of the NLRP3 Inflammasomes in Diabetes
title_full_unstemmed Modulatory Mechanisms of the NLRP3 Inflammasomes in Diabetes
title_short Modulatory Mechanisms of the NLRP3 Inflammasomes in Diabetes
title_sort modulatory mechanisms of the nlrp3 inflammasomes in diabetes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995523/
https://www.ncbi.nlm.nih.gov/pubmed/31835423
http://dx.doi.org/10.3390/biom9120850
work_keys_str_mv AT dingsujuan modulatorymechanismsofthenlrp3inflammasomesindiabetes
AT xusheng modulatorymechanismsofthenlrp3inflammasomesindiabetes
AT mayong modulatorymechanismsofthenlrp3inflammasomesindiabetes
AT liugang modulatorymechanismsofthenlrp3inflammasomesindiabetes
AT janghongmei modulatorymechanismsofthenlrp3inflammasomesindiabetes
AT fangjun modulatorymechanismsofthenlrp3inflammasomesindiabetes