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Trafficking of Stretch-Regulated TRPV2 and TRPV4 Channels Inferred Through Interactomics
Transient receptor potential cation channels are emerging as important physiological and therapeutic targets. Within the vanilloid subfamily, transient receptor potential vanilloid 2 (TRPV2) and 4 (TRPV4) are osmo- and mechanosensors becoming critical determinants in cell structure and activity. How...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995547/ https://www.ncbi.nlm.nih.gov/pubmed/31783610 http://dx.doi.org/10.3390/biom9120791 |
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author | Doñate-Macián, Pau Enrich-Bengoa, Jennifer Dégano, Irene R. Quintana, David G. Perálvarez-Marín, Alex |
author_facet | Doñate-Macián, Pau Enrich-Bengoa, Jennifer Dégano, Irene R. Quintana, David G. Perálvarez-Marín, Alex |
author_sort | Doñate-Macián, Pau |
collection | PubMed |
description | Transient receptor potential cation channels are emerging as important physiological and therapeutic targets. Within the vanilloid subfamily, transient receptor potential vanilloid 2 (TRPV2) and 4 (TRPV4) are osmo- and mechanosensors becoming critical determinants in cell structure and activity. However, knowledge is scarce regarding how TRPV2 and TRPV4 are trafficked to the plasma membrane or specific organelles to undergo quality controls through processes such as biosynthesis, anterograde/retrograde trafficking, and recycling. This review lists and reviews a subset of protein–protein interactions from the TRPV2 and TRPV4 interactomes, which is related to trafficking processes such as lipid metabolism, phosphoinositide signaling, vesicle-mediated transport, and synaptic-related exocytosis. Identifying the protein and lipid players involved in trafficking will improve the knowledge on how these stretch-related channels reach specific cellular compartments. |
format | Online Article Text |
id | pubmed-6995547 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-69955472020-02-13 Trafficking of Stretch-Regulated TRPV2 and TRPV4 Channels Inferred Through Interactomics Doñate-Macián, Pau Enrich-Bengoa, Jennifer Dégano, Irene R. Quintana, David G. Perálvarez-Marín, Alex Biomolecules Review Transient receptor potential cation channels are emerging as important physiological and therapeutic targets. Within the vanilloid subfamily, transient receptor potential vanilloid 2 (TRPV2) and 4 (TRPV4) are osmo- and mechanosensors becoming critical determinants in cell structure and activity. However, knowledge is scarce regarding how TRPV2 and TRPV4 are trafficked to the plasma membrane or specific organelles to undergo quality controls through processes such as biosynthesis, anterograde/retrograde trafficking, and recycling. This review lists and reviews a subset of protein–protein interactions from the TRPV2 and TRPV4 interactomes, which is related to trafficking processes such as lipid metabolism, phosphoinositide signaling, vesicle-mediated transport, and synaptic-related exocytosis. Identifying the protein and lipid players involved in trafficking will improve the knowledge on how these stretch-related channels reach specific cellular compartments. MDPI 2019-11-27 /pmc/articles/PMC6995547/ /pubmed/31783610 http://dx.doi.org/10.3390/biom9120791 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Doñate-Macián, Pau Enrich-Bengoa, Jennifer Dégano, Irene R. Quintana, David G. Perálvarez-Marín, Alex Trafficking of Stretch-Regulated TRPV2 and TRPV4 Channels Inferred Through Interactomics |
title | Trafficking of Stretch-Regulated TRPV2 and TRPV4 Channels Inferred Through Interactomics |
title_full | Trafficking of Stretch-Regulated TRPV2 and TRPV4 Channels Inferred Through Interactomics |
title_fullStr | Trafficking of Stretch-Regulated TRPV2 and TRPV4 Channels Inferred Through Interactomics |
title_full_unstemmed | Trafficking of Stretch-Regulated TRPV2 and TRPV4 Channels Inferred Through Interactomics |
title_short | Trafficking of Stretch-Regulated TRPV2 and TRPV4 Channels Inferred Through Interactomics |
title_sort | trafficking of stretch-regulated trpv2 and trpv4 channels inferred through interactomics |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995547/ https://www.ncbi.nlm.nih.gov/pubmed/31783610 http://dx.doi.org/10.3390/biom9120791 |
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