The Plasma Factor XIII Heterotetrameric Complex Structure: Unexpected Unequal Pairing within a Symmetric Complex

Factor XIII (FXIII) is a predominant determinant of clot stability, strength, and composition. Plasma FXIII circulates as a pro-transglutaminase with two catalytic A subunits and two carrier-protective B subunits in a heterotetramer (FXIII-A(2)B(2)). FXIII-A(2) and -B(2) subunits are synthesized sep...

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Detalles Bibliográficos
Autores principales: Singh, Sneha, Nazabal, Alexis, Kaniyappan, Senthilvelrajan, Pellequer, Jean-Luc, Wolberg, Alisa S., Imhof, Diana, Oldenburg, Johannes, Biswas, Arijit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995596/
https://www.ncbi.nlm.nih.gov/pubmed/31766577
http://dx.doi.org/10.3390/biom9120765

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995596/
https://www.ncbi.nlm.nih.gov/pubmed/31766577
http://dx.doi.org/10.3390/biom9120765

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