Exploration of the Misfolding Mechanism of Transthyretin Monomer: Insights from Hybrid-Resolution Simulations and Markov State Model Analysis

Misfolding and aggregation of transthyretin (TTR) is widely known to be responsible for a progressive systemic disorder called amyloid transthyretin (ATTR) amyloidosis. Studies suggest that TTR aggregation is initiated by a rate-limiting dissociation of the homo-tetramer into its monomers, which can...

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Detalles Bibliográficos
Autores principales: Zhou, Shuangyan, Cheng, Jie, Yang, Ting, Ma, Mingyue, Zhang, Wenying, Yuan, Shuai, Lo, Glenn V., Dou, Yusheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995605/
https://www.ncbi.nlm.nih.gov/pubmed/31861226
http://dx.doi.org/10.3390/biom9120889

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