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Sarcomatoid Chromophobe Renal Cell Carcinoma with Heterologous Component

Clear cell renal cell carcinoma (RCC) is the most common malignant renal tumor in adults, while chromophobe RCC (CRCC) is the third most common. Any subtypes of RCC can undergo sarcomatoid differentiation, but heterologous differentiation in sarcomatoid area is very rare in RCC. Here a 61-year male...

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Autores principales: Bharti, Sushma, Ram Choudhary, Gautam, Jyotsna Bharti, Naresh, Kumar Garg, Pawan, B.S, Arsha, Abhay Elhence, Poonam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iranian Society of Pathology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995683/
https://www.ncbi.nlm.nih.gov/pubmed/32095153
http://dx.doi.org/10.30699/IJP.2019.109242.2147
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author Bharti, Sushma
Ram Choudhary, Gautam
Jyotsna Bharti, Naresh
Kumar Garg, Pawan
B.S, Arsha
Abhay Elhence, Poonam
author_facet Bharti, Sushma
Ram Choudhary, Gautam
Jyotsna Bharti, Naresh
Kumar Garg, Pawan
B.S, Arsha
Abhay Elhence, Poonam
author_sort Bharti, Sushma
collection PubMed
description Clear cell renal cell carcinoma (RCC) is the most common malignant renal tumor in adults, while chromophobe RCC (CRCC) is the third most common. Any subtypes of RCC can undergo sarcomatoid differentiation, but heterologous differentiation in sarcomatoid area is very rare in RCC. Here a 61-year male is presented with hematuria and palpable mass. Clinicoradiologically, RCC was considered and left radical nephrectomy was performed. A well-circumscribed renal mass located in the upper pole of the left kidney with variegation and extensive areas of bony hard calcification noted, was reported as CRCC with sarcomatoid differentiation containing heterologous component. CRCC subtype has good prognosis but show dismal prognosis when associated with sarcomatous differentiation. We found 11 cases of sarcomatoid CRCC containing heterologous elements reported in indexed English literature. CRCC must be differentiated from Conventional RCC and Oncocytoma. The extensive sampling of the tumor is needed. We report a very rare case of CRCC with sarcomatoid differentiation containing heterologous elements.
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spelling pubmed-69956832020-02-24 Sarcomatoid Chromophobe Renal Cell Carcinoma with Heterologous Component Bharti, Sushma Ram Choudhary, Gautam Jyotsna Bharti, Naresh Kumar Garg, Pawan B.S, Arsha Abhay Elhence, Poonam Iran J Pathol Case Report Clear cell renal cell carcinoma (RCC) is the most common malignant renal tumor in adults, while chromophobe RCC (CRCC) is the third most common. Any subtypes of RCC can undergo sarcomatoid differentiation, but heterologous differentiation in sarcomatoid area is very rare in RCC. Here a 61-year male is presented with hematuria and palpable mass. Clinicoradiologically, RCC was considered and left radical nephrectomy was performed. A well-circumscribed renal mass located in the upper pole of the left kidney with variegation and extensive areas of bony hard calcification noted, was reported as CRCC with sarcomatoid differentiation containing heterologous component. CRCC subtype has good prognosis but show dismal prognosis when associated with sarcomatous differentiation. We found 11 cases of sarcomatoid CRCC containing heterologous elements reported in indexed English literature. CRCC must be differentiated from Conventional RCC and Oncocytoma. The extensive sampling of the tumor is needed. We report a very rare case of CRCC with sarcomatoid differentiation containing heterologous elements. Iranian Society of Pathology 2020 /pmc/articles/PMC6995683/ /pubmed/32095153 http://dx.doi.org/10.30699/IJP.2019.109242.2147 Text en © 2020 This is an open-access article distributed under the terms of the Creative Commons Attribution-noncommercial 4.0 International License, (https://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
spellingShingle Case Report
Bharti, Sushma
Ram Choudhary, Gautam
Jyotsna Bharti, Naresh
Kumar Garg, Pawan
B.S, Arsha
Abhay Elhence, Poonam
Sarcomatoid Chromophobe Renal Cell Carcinoma with Heterologous Component
title Sarcomatoid Chromophobe Renal Cell Carcinoma with Heterologous Component
title_full Sarcomatoid Chromophobe Renal Cell Carcinoma with Heterologous Component
title_fullStr Sarcomatoid Chromophobe Renal Cell Carcinoma with Heterologous Component
title_full_unstemmed Sarcomatoid Chromophobe Renal Cell Carcinoma with Heterologous Component
title_short Sarcomatoid Chromophobe Renal Cell Carcinoma with Heterologous Component
title_sort sarcomatoid chromophobe renal cell carcinoma with heterologous component
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995683/
https://www.ncbi.nlm.nih.gov/pubmed/32095153
http://dx.doi.org/10.30699/IJP.2019.109242.2147
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