Familial Mediterranean Fever Is Important in the Differential Diagnosis of Recurrent Aseptic Meningitis in Japan

Familial Mediterranean fever (FMF) is an autoinflammatory disease characterized by a recurrent fever and multiple serositis. In the present report, we discuss the case of a 42-year-old man diagnosed with FMF accompanied by recurrent aseptic meningitis (RAM). The patient experienced RAM at intervals...

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Autores principales: Hosoi, Takahiro, Ishii, Kazuhiro, Tozaka, Naoki, Kishida, Dai, Sekijima, Yoshiki, Tamaoka, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995700/
https://www.ncbi.nlm.nih.gov/pubmed/31511485
http://dx.doi.org/10.2169/internalmedicine.3432-19
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author Hosoi, Takahiro
Ishii, Kazuhiro
Tozaka, Naoki
Kishida, Dai
Sekijima, Yoshiki
Tamaoka, Akira
author_facet Hosoi, Takahiro
Ishii, Kazuhiro
Tozaka, Naoki
Kishida, Dai
Sekijima, Yoshiki
Tamaoka, Akira
author_sort Hosoi, Takahiro
collection PubMed
description Familial Mediterranean fever (FMF) is an autoinflammatory disease characterized by a recurrent fever and multiple serositis. In the present report, we discuss the case of a 42-year-old man diagnosed with FMF accompanied by recurrent aseptic meningitis (RAM). The patient experienced RAM at intervals of several years without any serositis or synovitis. We detected Mediterranean fever (MEFV) gene mutations (E148Q homozygotes) and diagnosed FMF in perfect accordance with clinical diagnostic criteria. FMF, in which RAM is a major symptom, has also been described in previous reports. Therefore, FMF should be considered in the differential diagnosis of causative diseases for RAM.
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spelling pubmed-69957002020-02-03 Familial Mediterranean Fever Is Important in the Differential Diagnosis of Recurrent Aseptic Meningitis in Japan Hosoi, Takahiro Ishii, Kazuhiro Tozaka, Naoki Kishida, Dai Sekijima, Yoshiki Tamaoka, Akira Intern Med Case Report Familial Mediterranean fever (FMF) is an autoinflammatory disease characterized by a recurrent fever and multiple serositis. In the present report, we discuss the case of a 42-year-old man diagnosed with FMF accompanied by recurrent aseptic meningitis (RAM). The patient experienced RAM at intervals of several years without any serositis or synovitis. We detected Mediterranean fever (MEFV) gene mutations (E148Q homozygotes) and diagnosed FMF in perfect accordance with clinical diagnostic criteria. FMF, in which RAM is a major symptom, has also been described in previous reports. Therefore, FMF should be considered in the differential diagnosis of causative diseases for RAM. The Japanese Society of Internal Medicine 2019-09-11 2020-01-01 /pmc/articles/PMC6995700/ /pubmed/31511485 http://dx.doi.org/10.2169/internalmedicine.3432-19 Text en Copyright © 2020 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Hosoi, Takahiro
Ishii, Kazuhiro
Tozaka, Naoki
Kishida, Dai
Sekijima, Yoshiki
Tamaoka, Akira
Familial Mediterranean Fever Is Important in the Differential Diagnosis of Recurrent Aseptic Meningitis in Japan
title Familial Mediterranean Fever Is Important in the Differential Diagnosis of Recurrent Aseptic Meningitis in Japan
title_full Familial Mediterranean Fever Is Important in the Differential Diagnosis of Recurrent Aseptic Meningitis in Japan
title_fullStr Familial Mediterranean Fever Is Important in the Differential Diagnosis of Recurrent Aseptic Meningitis in Japan
title_full_unstemmed Familial Mediterranean Fever Is Important in the Differential Diagnosis of Recurrent Aseptic Meningitis in Japan
title_short Familial Mediterranean Fever Is Important in the Differential Diagnosis of Recurrent Aseptic Meningitis in Japan
title_sort familial mediterranean fever is important in the differential diagnosis of recurrent aseptic meningitis in japan
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995700/
https://www.ncbi.nlm.nih.gov/pubmed/31511485
http://dx.doi.org/10.2169/internalmedicine.3432-19
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