Enhanced Delivery of Rituximab Into Brain and Lymph Nodes Using Timed-Release Nanocapsules in Non-Human Primates

Tumor metastasis into the central nervous system (CNS) and lymph nodes (LNs) is a major obstacle for effective therapies. Therapeutic monoclonal antibodies (mAb) have revolutionized tumor treatment; however, their efficacy for treating metastatic tumors-particularly, CNS and LN metastases-is poor du...

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Detalles Bibliográficos
Autores principales: Qin, Meng, Wang, Lan, Wu, Di, Williams, Christopher K., Xu, Duo, Kranz, Emiko, Guo, Qi, Guan, Jiaoqiong, Vinters, Harry V., Lee, YooJin, Xie, Yiming, Luo, Yun, Sun, Guibo, Sun, Xiaobo, He, Zhanlong, Lu, Yunfeng, Kamata, Masakazu, Wen, Jing, Chen, Irvin S. Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996053/
https://www.ncbi.nlm.nih.gov/pubmed/32047498
http://dx.doi.org/10.3389/fimmu.2019.03132

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