hnRNPDL Phase Separation Is Regulated by Alternative Splicing and Disease-Causing Mutations Accelerate Its Aggregation

Prion-like proteins form multivalent assemblies and phase separate into membraneless organelles. Heterogeneous ribonucleoprotein D-like (hnRNPDL) is a RNA-processing prion-like protein with three alternative splicing (AS) isoforms, which lack none, one, or both of its two disordered domains. It has...

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Detalles Bibliográficos
Autores principales: Batlle, Cristina, Yang, Peiguo, Coughlin, Maura, Messing, James, Pesarrodona, Mireia, Szulc, Elzbieta, Salvatella, Xavier, Kim, Hong Joo, Taylor, J. Paul, Ventura, Salvador
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996132/
https://www.ncbi.nlm.nih.gov/pubmed/31995753
http://dx.doi.org/10.1016/j.celrep.2019.12.080

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996132/
https://www.ncbi.nlm.nih.gov/pubmed/31995753
http://dx.doi.org/10.1016/j.celrep.2019.12.080

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