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Bile acid receptor agonists in primary biliary cholangitis: Regulation of the cholangiocyte secretome and downstream T cell differentiation

Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease. Approximately 30% of patients do not respond to therapy with ursodeoxycholic acid (UDCA). Previous studies have implicated increased senescence of cholangiocytes in patients who do not respond to UDCA. This may increase the rel...

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Detalles Bibliográficos
Autores principales: Etherington, Rachel E., Millar, Benjamin J. M., Innes, Barbara A., Jones, David E. J., Kirby, John A., Brain, John G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996327/
https://www.ncbi.nlm.nih.gov/pubmed/32123836
http://dx.doi.org/10.1096/fba.2018-00046