Losing maleness: Somatic Y chromosome loss at every stage of a man's life

Mosaic loss of Y chromosome (LOY) is assumed to be among the most common acquired genetic variations in elderly people. Recent studies have linked aging‐related mosaic LOY to the risk of Alzheimer's disease, cancer, and early death. Here, we propose that mosaic LOY can present in men at any age...

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Detalles Bibliográficos
Autores principales: Miyado, Mami, Fukami, Maki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Hypothesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996334/
https://www.ncbi.nlm.nih.gov/pubmed/32123838
http://dx.doi.org/10.1096/fba.2019-00006
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author Miyado, Mami
Fukami, Maki
author_facet Miyado, Mami
Fukami, Maki
author_sort Miyado, Mami
collection PubMed
description Mosaic loss of Y chromosome (LOY) is assumed to be among the most common acquired genetic variations in elderly people. Recent studies have linked aging‐related mosaic LOY to the risk of Alzheimer's disease, cancer, and early death. Here, we propose that mosaic LOY can present in men at any age. Mosaic LOY appears to be associated with disorders of sex development and Turner syndrome at birth, short stature from childhood, and spermatogenic failure at reproductive age, in addition to shortened survival after 60 years of age.
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spelling pubmed-69963342020-03-02 Losing maleness: Somatic Y chromosome loss at every stage of a man's life Miyado, Mami Fukami, Maki FASEB Bioadv Hypothesis Mosaic loss of Y chromosome (LOY) is assumed to be among the most common acquired genetic variations in elderly people. Recent studies have linked aging‐related mosaic LOY to the risk of Alzheimer's disease, cancer, and early death. Here, we propose that mosaic LOY can present in men at any age. Mosaic LOY appears to be associated with disorders of sex development and Turner syndrome at birth, short stature from childhood, and spermatogenic failure at reproductive age, in addition to shortened survival after 60 years of age. John Wiley and Sons Inc. 2019-04-02 /pmc/articles/PMC6996334/ /pubmed/32123838 http://dx.doi.org/10.1096/fba.2019-00006 Text en © 2019 The Authors This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Hypothesis
Miyado, Mami
Fukami, Maki
Losing maleness: Somatic Y chromosome loss at every stage of a man's life
title Losing maleness: Somatic Y chromosome loss at every stage of a man's life
title_full Losing maleness: Somatic Y chromosome loss at every stage of a man's life
title_fullStr Losing maleness: Somatic Y chromosome loss at every stage of a man's life
title_full_unstemmed Losing maleness: Somatic Y chromosome loss at every stage of a man's life
title_short Losing maleness: Somatic Y chromosome loss at every stage of a man's life
title_sort losing maleness: somatic y chromosome loss at every stage of a man's life
topic Hypothesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996334/
https://www.ncbi.nlm.nih.gov/pubmed/32123838
http://dx.doi.org/10.1096/fba.2019-00006
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