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Development of a whole‐cell high‐throughput phenotypic screen to identify inhibitors of mycobacterial amino acid biosynthesis

Anti‐tubercular drug discovery continues to be dominated by whole‐cell high‐throughput screening campaigns, enabling the rapid discovery of new inhibitory chemical scaffolds. Target‐based screening is a popular approach to direct inhibitor discovery with a specified mode of action, eliminating the d...

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Detalles Bibliográficos
Autores principales:	Burke, Christopher, Abrahams, Katherine A., Richardson, Emily J., Loman, Nicholas J., Alemparte, Carlos, Lelievre, Joel, Besra, Gurdyal S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996392/ https://www.ncbi.nlm.nih.gov/pubmed/32123830 http://dx.doi.org/10.1096/fba.2018-00048

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