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Prostate Cancer Cellular Uptake of Ternary Titanate Nanotubes/CuFe(2)O(4)/Zn-Fe Mixed Metal Oxides Nanocomposite

BACKGROUND: Certainly, there is a demand for stronger recognition of how nanoparticles can move through the cell membrane. Prostate cancer is one of the forcing sources of cancer-relevant deaths among men. AIM OF THE WORK: The current research studied the power of prostate cancer cells to uptake a t...

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Detalles Bibliográficos
Autores principales: El-Shahawy, Ahmed AG, Abdel Moaty, SA, Zaki, AH, Mohamed, Nada A, GadelHak, Yasser, Mahmoud, RK, Farghali, AA
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996550/
https://www.ncbi.nlm.nih.gov/pubmed/32099355
http://dx.doi.org/10.2147/IJN.S228279
Descripción
Sumario:BACKGROUND: Certainly, there is a demand for stronger recognition of how nanoparticles can move through the cell membrane. Prostate cancer is one of the forcing sources of cancer-relevant deaths among men. AIM OF THE WORK: The current research studied the power of prostate cancer cells to uptake a ternary nanocomposite TNT/CuFe(2)O(4)/Zn-Fe mixed metal oxides (MMO). METHODOLOGY: The nanocomposite was synthesized by a chemical method and characterized by a High-resolution transmission electron microscope, Field emission scanning electron microscope, X-ray diffraction, Fourier transmission infra-red, X-ray photoelectron spectroscopy, dynamic light scattering. Besides, it was implemented as an inorganic anticancer agent versus Prostate cancer PC-3 cells. RESULTS: The results revealed cellular uptake validity, cell viability reduction, ultra-structures alterations, morphological changes and membrane damage of PC-3 cells. CONCLUSION: The prepared ternary nanocomposite was highly uptake by PC-3 cells and possessed cytotoxicity that was dose and time-dependent. To conclude, the study offered the potential of the investigated ternary nanocomposite as a promising prostate anticancer agent.