The Anti-Cancer Mechanisms of Berberine: A Review

Berberine (BBR) has been extensively studied in vivo and vitro experiments. BBR inhibits cell proliferation by regulating cell cycle and cell autophagy, and promoting cell apoptosis. BBR also inhibits cell invasion and metastasis by suppressing EMT and down-regulating the expression of metastasis-re...

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Detalles Bibliográficos
Autores principales: Wang, Ye, Liu, Yanfang, Du, Xinyang, Ma, Hong, Yao, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996556/
https://www.ncbi.nlm.nih.gov/pubmed/32099466
http://dx.doi.org/10.2147/CMAR.S242329
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author Wang, Ye
Liu, Yanfang
Du, Xinyang
Ma, Hong
Yao, Jing
author_facet Wang, Ye
Liu, Yanfang
Du, Xinyang
Ma, Hong
Yao, Jing
author_sort Wang, Ye
collection PubMed
description Berberine (BBR) has been extensively studied in vivo and vitro experiments. BBR inhibits cell proliferation by regulating cell cycle and cell autophagy, and promoting cell apoptosis. BBR also inhibits cell invasion and metastasis by suppressing EMT and down-regulating the expression of metastasis-related proteins and signaling pathways. In addition, BBR inhibits cell proliferation by interacting with microRNAs and suppressing telomerase activity. BBR exerts its anti-inflammation and antioxidant properties, and also regulates tumor microenvironment. This review emphasized that BBR as a potential anti-inflammation and antioxidant agent, also as an effective immunomodulator, is expected to be widely used in clinic for cancer therapy.
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spelling pubmed-69965562020-02-25 The Anti-Cancer Mechanisms of Berberine: A Review Wang, Ye Liu, Yanfang Du, Xinyang Ma, Hong Yao, Jing Cancer Manag Res Review Berberine (BBR) has been extensively studied in vivo and vitro experiments. BBR inhibits cell proliferation by regulating cell cycle and cell autophagy, and promoting cell apoptosis. BBR also inhibits cell invasion and metastasis by suppressing EMT and down-regulating the expression of metastasis-related proteins and signaling pathways. In addition, BBR inhibits cell proliferation by interacting with microRNAs and suppressing telomerase activity. BBR exerts its anti-inflammation and antioxidant properties, and also regulates tumor microenvironment. This review emphasized that BBR as a potential anti-inflammation and antioxidant agent, also as an effective immunomodulator, is expected to be widely used in clinic for cancer therapy. Dove 2020-01-30 /pmc/articles/PMC6996556/ /pubmed/32099466 http://dx.doi.org/10.2147/CMAR.S242329 Text en © 2020 Wang et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Wang, Ye
Liu, Yanfang
Du, Xinyang
Ma, Hong
Yao, Jing
The Anti-Cancer Mechanisms of Berberine: A Review
title The Anti-Cancer Mechanisms of Berberine: A Review
title_full The Anti-Cancer Mechanisms of Berberine: A Review
title_fullStr The Anti-Cancer Mechanisms of Berberine: A Review
title_full_unstemmed The Anti-Cancer Mechanisms of Berberine: A Review
title_short The Anti-Cancer Mechanisms of Berberine: A Review
title_sort anti-cancer mechanisms of berberine: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996556/
https://www.ncbi.nlm.nih.gov/pubmed/32099466
http://dx.doi.org/10.2147/CMAR.S242329
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