Blockade of Stat3 oncogene addiction induces cellular senescence and reveals a cell-nonautonomous activity suitable for cancer immunotherapy

Stat3 is constitutively activated in several tumor types and plays an essential role in maintaining their malignant phenotype and immunosupression. To take advantage of the promising antitumor activity of Stat3 targeting, it is vital to understand the mechanism by which Stat3 regulates both cell aut...

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Detalles Bibliográficos
Autores principales: De Martino, Mara, Tkach, Mercedes, Bruni, Sofía, Rocha, Darío, Mercogliano, María F., Cenciarini, Mauro E., Chervo, María F., Proietti, Cecilia J., Dingli, Florent, Loew, Damarys, Fernández, Elmer A., Elizalde, Patricia V., Piaggio, Eliane, Schillaci, Roxana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996562/
https://www.ncbi.nlm.nih.gov/pubmed/32064174
http://dx.doi.org/10.1080/2162402X.2020.1715767

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