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Synthesis and Antitumor Evaluation of Novel Hybrids of Phenylsulfonylfuroxan and Estradiol Derivatives

Fifteen novel furoxan‐based nitric oxide (NO) releasing hybrids of estradiol derivatives were synthesized and evaluated in vitro anti‐proliferative activity in MDA‐MB‐231, A2780, Hela and HUVEC cell lines. Most of them displayed potent anti‐proliferative effects. Among the compounds, 4‐bromo‐3‐((phe...

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Detalles Bibliográficos
Autores principales: Wan, Qi, Deng, Yan, Huang, Yaoqing, Yu, Zhihui, Wang, Chunli, Wang, Ke, Dong, Jibin, Chen, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996566/
https://www.ncbi.nlm.nih.gov/pubmed/32025462
http://dx.doi.org/10.1002/open.201900228