NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor

The intestinal stem cell (ISC) marker LGR5 is a receptor for R‐spondin (RSPO) that functions to potentiate Wnt signalling in the proliferating crypt. It has been recently shown that Wnt plays a priming role for ISC self‐renewal by inducing RSPO receptor LGR5 expression. Despite its pivotal role in h...

Descripción completa

Detalles Bibliográficos
Autores principales: Novellasdemunt, Laura, Kucharska, Anna, Jamieson, Cara, Prange‐Barczynska, Maria, Baulies, Anna, Antas, Pedro, van der Vaart, Jelte, Gehart, Helmuth, Maurice, Madelon M, Li, Vivian SW
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996568/
https://www.ncbi.nlm.nih.gov/pubmed/31867777
http://dx.doi.org/10.15252/embj.2019102771

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996568/
https://www.ncbi.nlm.nih.gov/pubmed/31867777
http://dx.doi.org/10.15252/embj.2019102771

Ejemplares similares