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NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor
The intestinal stem cell (ISC) marker LGR5 is a receptor for R‐spondin (RSPO) that functions to potentiate Wnt signalling in the proliferating crypt. It has been recently shown that Wnt plays a priming role for ISC self‐renewal by inducing RSPO receptor LGR5 expression. Despite its pivotal role in h...
Autores principales: | Novellasdemunt, Laura, Kucharska, Anna, Jamieson, Cara, Prange‐Barczynska, Maria, Baulies, Anna, Antas, Pedro, van der Vaart, Jelte, Gehart, Helmuth, Maurice, Madelon M, Li, Vivian SW |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996568/ https://www.ncbi.nlm.nih.gov/pubmed/31867777 http://dx.doi.org/10.15252/embj.2019102771 |
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